Shiraishi Kamma, Sakane Satoshi, Hara Kentaro, Koshino Yasuyuki, Ago Hiroatsu, Endo Akira, Ooi Shinji
Department of Hematology, Matsue Red Cross Hospital, Shimane, Japan.
Department of Laboratory Medicine, Matsue Red Cross Hospital, Shimane, Japan.
Radiol Case Rep. 2024 May 3;19(8):2965-2968. doi: 10.1016/j.radcr.2024.03.094. eCollection 2024 Aug.
A 59-year-old man with pancytopenia underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography for suspected carcinomatosis. The scan revealed diffuse bone marrow uptake, prompting further investigation. Bone marrow analysis revealed no malignant cells; however, erythroblasts with cytoplasmic vacuolization were observed. Subsequent testing showed low serum copper and ceruloplasmin levels, indicating copper deficiency. Copper supplementation resulted in significant improvement in cytopenia. Notably, the bone marrow uptake on subsequent scans decreased significantly. This case highlights the importance of considering copper deficiency as a potential cause of diffuse bone marrow uptake of F-fluorodeoxyglucose on positron emission tomography/computed tomography.
一名患有全血细胞减少症的59岁男性因疑似癌转移接受了18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描。扫描显示骨髓弥漫性摄取，促使进一步检查。骨髓分析未发现恶性细胞；然而，观察到有细胞质空泡化的成红细胞。随后的检测显示血清铜和铜蓝蛋白水平较低，表明铜缺乏。补充铜后全血细胞减少症有显著改善。值得注意的是，后续扫描中骨髓摄取明显减少。该病例强调了在正电子发射断层扫描/计算机断层扫描中考虑铜缺乏作为F-氟脱氧葡萄糖骨髓弥漫性摄取潜在原因的重要性。
