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[化脓性肺部疾病患者的免疫反应性及免疫纠正治疗的有效性]

[Immunological reactivity of patients with suppurative lung diseases and the effectiveness of immunocorrective therapy].

作者信息

Gubergrits A Ia, Sokhin A A, Monogarova N E, Kurilova V G

出版信息

Ter Arkh. 1985;57(3):55-8.

PMID:3873719
Abstract

Patients with acute lung abscesses and bronchiectatic diseases manifested deep changes in the immune responsiveness, which were largely of compensatory (elevation of IgA content to over 2 mg/ml), immunosuppressive (decrease of lymphocyte blast transformation with PHA down to 52.2 and 48.6%) or autoimmune (increase of spontaneous lymphocyte blast transformation up to 8%) character. In patients with acute lung abscesses, the indicators enumerated tended during treatment toward normalization which was not over in the majority of them by the discharge from hospital. In patients with bronchiectatic disease, that tendency was observable only after additional treatment with immunocorrective drugs (levamisole, splenin).

摘要

急性肺脓肿和支气管扩张疾病患者表现出免疫反应性的深刻变化,这些变化在很大程度上具有代偿性(IgA含量升高至超过2mg/ml)、免疫抑制性(用PHA刺激时淋巴细胞转化降低至52.2%和48.6%)或自身免疫性(自发淋巴细胞转化增加至8%)的特征。在急性肺脓肿患者中,上述指标在治疗期间趋于正常,但大多数患者在出院时并未完全恢复正常。在支气管扩张疾病患者中,只有在使用免疫纠正药物(左旋咪唑、脾制剂)进行额外治疗后才观察到这种趋势。

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