Irani Emaun, Macleod Colin, Slat Stephanie, Kehne Adrianne, Madden Erin, Jaffe Kaitlyn, Bohnert Amy, Lagisetty Pooja
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
VA Center for Clinical Management Research (CCMR), VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Drug Alcohol Depend Rep. 2024 Apr 24;11:100235. doi: 10.1016/j.dadr.2024.100235. eCollection 2024 Jun.
Negative perceptions around medications for opioid use disorder (MOUD) amongst the public could deter patients with opioid use disorder (OUD) from engaging with MOUD. Thus, we evaluated whether a brief intervention could improve preferences for MOUD in people who may or may not use opioids.
We employed a pre-post design to assess the effect of a brief educational intervention on preferences for methadone, buprenorphine, naltrexone, and non-medication treatment in an online sample of US adults stratified by race, who may or may not use opioids. Respondents ranked their preferences in OUD treatment before and after watching four one-minute educational videos about treatment options. Changes in treatment preferences were analyzed using Bhapkar's test and post hoc McNemar's tests. A binary logistic generalized estimating equation (GEE) assessed factors associated with preference between treatments.
The sample had 530 responses. 194 identified as White, 173 Black, 163 Latinx. Treatment preferences changed significantly towards MOUD (p<.001). This effect was driven by changes toward buprenorphine (OR=2.38; p<.001) and away from non-medication treatment (OR=0.20; p<.001). There was no significant difference in effect by race/ethnicity. People with lower opioid familiarity were significantly more likely to change their preferences towards MOUD following the intervention.
Respondent preferences for MOUD increased following the intervention suggesting that brief educational interventions can change treatment preferences towards MOUD. These findings offer insights into perceptions of OUD treatment in a racially stratified sample and serve as a foundation for future educational materials that target MOUD preferences in the general public.
公众对阿片类物质使用障碍药物治疗（MOUD）的负面看法可能会阻碍阿片类物质使用障碍（OUD）患者接受MOUD治疗。因此，我们评估了一种简短干预措施是否能改善可能使用或不使用阿片类药物的人群对MOUD的偏好。
我们采用前后测设计，以评估一项简短教育干预措施对美国成年在线样本中按种族分层的、可能使用或不使用阿片类药物的人群对美沙酮、丁丙诺啡、纳曲酮和非药物治疗的偏好的影响。受访者在观看关于治疗选择的四个一分钟教育视频之前和之后对OUD治疗的偏好进行了排序。使用Bhapkar检验和事后McNemar检验分析治疗偏好的变化。二元逻辑广义估计方程（GEE）评估与治疗间偏好相关的因素。
样本有530份回复。194人被认定为白人，173人为黑人，163人为拉丁裔。对MOUD的治疗偏好发生了显著变化（p<0.001）。这种效应是由对丁丙诺啡的偏好变化（OR=2.38；p<0.001）和对非药物治疗的偏好下降（OR=0.20；p<0.001）驱动的。种族/族裔之间的效应没有显著差异。阿片类药物熟悉程度较低的人在干预后更有可能改变对MOUD的偏好。
干预后受访者对MOUD的偏好增加，表明简短教育干预可以改变对MOUD的治疗偏好。这些发现为种族分层样本中对OUD治疗的看法提供了见解，并为未来针对普通公众MOUD偏好的教育材料奠定了基础。
