Wang Zehao, Liu Zheng, Zhuang Lulu, Yin Weihua, Zhao Yongsheng, Dong Mengjie
Department of Nuclear Medicine, Peking University Shenzhen Hospital Shenzhen, Guangdong, China.
Shantou University Medical College Shantou, Guangdong, China.
Am J Nucl Med Mol Imaging. 2024 Apr 25;14(2):157-160. doi: 10.62347/WSUV5599. eCollection 2024.
Adenoid cystic carcinoma (ACC) is a rare salivary gland cancer. Still, its growth and invasion progress is slow, and its hematogenous metastasis is ACC's most common distant metastasis. Because of the broad expression and low background uptake of fibroblast activation protein (FAP) in tumor stroma, FAPI is considered another potential tracer of ACC in addition to FDG. In this case, we report a patient who was diagnosed with metastatic ACC liver cancer by fine needle aspiration biopsy (FNAB) and underwent PET/CT examination of [F]FDG and [F]FAPI-42 to find the primary cancer lesion. Finally, the primary cancer lesion was found in the left submandibular gland and was pathologically confirmed as ACC after resection.
腺样囊性癌（ACC）是一种罕见的唾液腺癌。不过，其生长和侵袭进展缓慢，血行转移是ACC最常见的远处转移方式。由于成纤维细胞活化蛋白（FAP）在肿瘤基质中广泛表达且背景摄取较低，FAPI被认为是除FDG之外ACC的另一种潜在示踪剂。在此病例中，我们报告了一名经细针穿刺活检（FNAB）诊断为转移性ACC肝癌的患者，并对其进行了[F]FDG和[F]FAPI-42的PET/CT检查以寻找原发癌灶。最终，在左下颌下腺发现了原发癌灶，切除后经病理证实为ACC。
