Henriksen L, Boas J
Acta Neurol Scand. 1985 Apr;71(4):257-66. doi: 10.1111/j.1600-0404.1985.tb03198.x.
Regional and mean cerebral blood flow (rCBF, CBF) were measured by tomography of inhaled 133Xe in 18 hemiparkinsonian patients before and after levodopa (L-dopa). Baseline mean CBF was 55 ml/ (100 g X min) after an L-dopa-free interval of at least 10 h (range 10-13) and remained unchanged at 56.1 ml/ (100 g X min) after optimal clinical improvement was achieved by L-dopa. However, L-dopa reduced rCBF significantly (P less than 0.05) in the striatum contralateral to the symptomatic limbs. In patients with adverse reactions such as hyperkinesias and on/off symptoms, flow tended to increase bilaterally in striatum and often markedly in midline structures anatomically related to globus pallidus and thalamus. Compared with a normal population, the subcortical rCBF distribution was asymmetrical with a reduced flow (-18%) in the striatum contralateral to the symptomatic limbs and in midline structures anatomically related to globus pallidus and thalamus (-12%). Cortical CBF was inverse related to the duration of Parkinson's disease (P less than 0.05), probably reflecting an increasing mental deterioration with time.
对18例偏侧帕金森病患者在左旋多巴（L -多巴）治疗前后，通过吸入133Xe断层扫描测量局部脑血流量（rCBF）和平均脑血流量（CBF）。在至少10小时（范围10 - 13小时）无L -多巴的间隔期后，基线平均CBF为55 ml/（100 g×分钟），在L -多巴实现最佳临床改善后，保持在56.1 ml/（100 g×分钟）不变。然而，L -多巴使症状肢体对侧纹状体的rCBF显著降低（P＜0.05）。在出现异动症和开关现象等不良反应的患者中，纹状体双侧血流量往往增加，与苍白球和丘脑相关的中线结构血流量常明显增加。与正常人群相比，皮质下rCBF分布不对称，症状肢体对侧纹状体以及与苍白球和丘脑相关的中线结构血流量减少（-18%）和（-12%）。皮质CBF与帕金森病病程呈负相关（P＜0.05），这可能反映出随着时间推移精神衰退加剧。
