Melamed E, Lavy S, Cooper G, Bentin S
J Neurol Sci. 1978 Oct;38(3):391-7. doi: 10.1016/0022-510x(78)90144-2.
Data from recent studies in experimental animals suggest that central dopaminergic mechanisms may be involved in regulation of the regional cerebral blood flow (rCBF) in the mammalian brain. In order to evaluate possible effects of dopaminergic stimulation on human cerebral circulation, rCBF was measured by the 133Xenon inhalation technique in 26 patients with Parkinson's disease before and after the chronic oral administration of levodopa combined with a peripheral Dopa-decarboxylase inhibitor. Treatment with levodopa did not induce significant alterations in the mean brain, mean hemispheric or regional flow values in these patients. These findings suggest that the dopaminergic system does not play an important role in modulation of the rCBF in man.
近期对实验动物的研究数据表明，中枢多巴胺能机制可能参与了哺乳动物大脑局部脑血流量（rCBF）的调节。为了评估多巴胺能刺激对人体脑循环的可能影响，采用133氙吸入技术，对26例帕金森病患者在长期口服左旋多巴联合外周多巴脱羧酶抑制剂前后进行了rCBF测量。左旋多巴治疗并未引起这些患者大脑平均血流量、半球平均血流量或局部血流量值的显著改变。这些发现提示，多巴胺能系统在调节人类rCBF方面并不起重要作用。
