Otsuka Shinya, Hiraoka Kei, Iwashiro Nozomu, Kimura Noriko, Ohara Masanori
Department of Surgery, National Hospital Organization (NHO) Hakodate National Hospital, Hakodate, Hokkaido, Japan.
Department of Diagnostic Pathology, NHO Hakodate National Hospital, Hakodate, Hokkaido, Japan.
Respir Med Case Rep. 2024 May 1;49:102033. doi: 10.1016/j.rmcr.2024.102033. eCollection 2024.
Mixed invasive mucinous and non-mucinous adenocarcinoma is a rare variant of lung adenocarcinoma. In pure invasive mucinous adenocarcinoma, multilobar and bilateral involvement are common, and extrathoracic metastasis is rare. Here, we report a case of mixed invasive mucinous and non-mucinous adenocarcinoma with distant metastasis to multiple organs without marked enlargement of the primary lung lesion. The pathological findings indicated high tumor invasiveness and the patient died 10 months after diagnosis despite chemoimmunotherapy. Further investigations are necessary to elucidate the clinical characteristics and appropriate management of mixed invasive mucinous and non-mucinous adenocarcinoma.
混合性浸润性黏液性和非黏液性腺癌是肺腺癌的一种罕见变异型。在纯浸润性黏液性腺癌中，多叶和双侧受累常见，而胸外转移罕见。在此，我们报告一例混合性浸润性黏液性和非黏液性腺癌，发生多器官远处转移，而原发性肺病灶无明显增大。病理结果显示肿瘤侵袭性高，尽管进行了化疗免疫治疗，患者在诊断后10个月死亡。有必要进一步研究以阐明混合性浸润性黏液性和非黏液性腺癌的临床特征及合适的治疗方法。
