Faculty of Pharmaceutical Sciences, Baba MastNath University, Rohtak, 124021, Haryana, India.
Amity Institute of Pharmacy, Amity University, Gurugram, 122413, Haryana, India.
Curr Top Med Chem. 2024;24(18):1529-1541. doi: 10.2174/0115680266296096240408032738.
Benzodiazepines are commonly prescribed drugs for numerous indications such as epilepsy, anti-anxiety, sleep aids, sedatives, and hypnotics. Although the well-tolerated effects of benzodiazepine are seen in many clinical instances, the severity of side effects reduces its quantifiable use. Benzodiazepines, which are medically useful but theoretically unsafe, are frequently recommended by medical practitioners for psychotic patients but have misuse and dependence liabilities. It is impelled as a debateable topic globally about which no one talks. These drugs are also known as silent killers because abruptly stopping them can result in tremors, muscle spasticity, and life-frightening seizures. These drugs are beneficial as well as risky. Nonclinical treatment is simple and well suited and provides support for patients suffering from side effects generated by benzodiazepine withdrawal. This review mainly focuses on antipsychotic drugs and their mechanisms, mortality, withdrawal, abuse, and management via clinical and nonclinical therapies.
苯二氮䓬类药物通常被开用于多种适应症，如癫痫、抗焦虑、助眠、镇静和催眠。尽管在许多临床情况下，苯二氮䓬类药物的耐受性良好，但副作用的严重程度限制了其量化使用。苯二氮䓬类药物在医学上有用但理论上不安全，经常被精神科医生推荐给精神病患者，但存在误用和依赖的风险。这是一个在全球范围内引发争议但无人谈论的话题。这些药物也被称为“沉默杀手”，因为突然停止使用它们可能导致震颤、肌肉痉挛和危及生命的癫痫发作。这些药物既有好处也有风险。非临床治疗简单且非常适合，并为因苯二氮䓬类药物戒断而产生副作用的患者提供支持。本综述主要关注抗精神病药物及其机制、死亡率、戒断、滥用以及通过临床和非临床治疗进行管理。
