Rudolf K, Göretzlehner G, Kunkel S
Endokrinologie. 1979;73(3):287-95.
In 9 female patients suffering from acute anorexia nervosa (a.n.) and in two patients in whom this disease had reached the remission phase, the response of the gonadotropin-producing cells in the adenohypophysis was checked by administration of Gn-RH and the degree to which the hypothalamic-hypophyseal axis could be stimulated was checked by administration of clomiphene (5 x 100 mg). Hormonal screening examinations (cervical score after Insler and hormonal vaginal cytology) were used to assay the basal estrogen production. LH and FSH concentrations in the serum were determined radioimmunologically using the principles of the double antibody technique. The gonadotropin-producing cells did not respond to Gn-RH administration in 8 of the 9 patients with acute a.n. The response was disturbed in one of these patients. The response to Gn-RH stimulation was normal in the two patients in the remission phase. Clomiphene had no stimulatory effect on the hypothalamic-hypophyseal axis during either the acute or remission phase. Hormonal treatment during the acute phase of a.n. is not indicated since, after recovery of a normal body weight, the symptoms recede and the cycle normalises spontaneously.
对9例急性神经性厌食症（a.n.）女性患者以及2例病情处于缓解期的该疾病患者，通过注射促性腺激素释放激素（Gn-RH）来检查腺垂体中促性腺激素分泌细胞的反应，并通过服用克罗米芬（5×100毫克）来检查下丘脑-垂体轴能够被刺激的程度。采用激素筛查检查（因斯勒宫颈评分法及激素阴道细胞学检查）来测定基础雌激素分泌量。血清中促黄体生成素（LH）和促卵泡生成素（FSH）的浓度采用双抗体技术原理通过放射免疫法测定。9例急性a.n.患者中有8例的促性腺激素分泌细胞对注射Gn-RH无反应。其中1例患者反应紊乱。2例处于缓解期的患者对Gn-RH刺激的反应正常。克罗米芬在急性或缓解期对下丘脑-垂体轴均无刺激作用。急性a.n.期不建议进行激素治疗，因为体重恢复正常后，症状会消退，月经周期会自发恢复正常。
