Vailati G, Montini M, Ongaro A, Pagani G
Minerva Med. 1976 Apr 30;67(21):1389-93.
The hypophyseal gonadotrophin LH reserve was studied in 9 adult women, 5 of whom were suffering from nervous anorexia (N.A.) and 4 normal, by means of subcutaneous injection of 50 mcg of synthetic GN-RH. Basal values of plasmatic LH proved to be significantly lower in N.A. than in the controls where the response to GN-RH was prompt. In patients with N.A., on the other hand, response was practically absent and differences were significant at all stages of the test. The parallel study of basal steroiduria and following methopirone confirmed the torpid hypophyseal response in N.A. These findings confirm previous personal reports and indicate that the GN-RH test is a useful technique for diagnostic and prognostic definition of N.A.
通过皮下注射50微克合成促性腺激素释放激素（GN-RH），对9名成年女性的垂体促性腺激素LH储备进行了研究，其中5名患有神经性厌食症（N.A.），4名正常。结果表明，N.A.患者血浆LH的基础值明显低于对照组，而对照组对GN-RH的反应迅速。另一方面，N.A.患者几乎没有反应，且在测试的各个阶段差异均有统计学意义。对基础类固醇尿症和甲吡酮给药后的平行研究证实了N.A.患者垂体反应迟钝。这些发现证实了之前个人报告的结果，并表明GN-RH试验是一种用于神经性厌食症诊断和预后判断的有用技术。
