Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Brain Struct Funct. 2024 Nov;229(8):1913-1925. doi: 10.1007/s00429-024-02773-9. Epub 2024 May 13.
The subdivisions of the extended cingulate cortex of the human brain are implicated in a number of high-level behaviors and affected by a range of neuropsychiatric disorders. Its anatomy, function, and response to therapeutics are often studied using non-human animals, including the mouse. However, the similarity of human and mouse frontal cortex, including cingulate areas, is still not fully understood. Some accounts emphasize resemblances between mouse cingulate cortex and human cingulate cortex while others emphasize similarities with human granular prefrontal cortex. We use comparative neuroimaging to study the connectivity of the cingulate cortex in the mouse and human, allowing comparisons between mouse 'gold standard' tracer and imaging data, and, in addition, comparison between the mouse and the human using comparable imaging data. We find overall similarities in organization of the cingulate between species, including anterior and midcingulate areas and a retrosplenial area. However, human cingulate contains subareas with a more fine-grained organization than is apparent in the mouse and it has connections to prefrontal areas not present in the mouse. Results such as these help formally address between-species brain organization and aim to improve the translation from preclinical to human results.
人脑扣带皮层的细分区域与许多高级行为有关，并受一系列神经精神疾病的影响。其解剖结构、功能和对治疗的反应通常在包括小鼠在内的非人类动物中进行研究。然而，人类和小鼠前额叶皮层（包括扣带区域）的相似性仍未完全理解。一些观点强调了小鼠扣带皮层与人类扣带皮层之间的相似性，而另一些观点则强调了与人类颗粒前额叶皮层的相似性。我们使用比较神经影像学来研究小鼠和人类扣带皮层的连接，允许在小鼠“金标准”示踪剂和成像数据之间进行比较，并且，除了使用可比的成像数据在小鼠和人类之间进行比较。我们发现，在物种之间，包括前扣带区和中扣带区以及后扣带区，扣带皮层的组织总体上具有相似性。然而，人类扣带皮层包含比小鼠中更精细的组织亚区，并且与小鼠中不存在的前额叶区域有联系。这样的结果有助于正式解决物种间大脑组织的问题，并旨在提高从临床前到人类结果的转化。
