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帕金森病的MPTP灵长类动物模型：一项力学描记法和肌电图研究。

MPTP primate model of Parkinson's disease: a mechanographic and electromyographic study.

作者信息

Doudet D, Gross C, Lebrun-Grandie P, Bioulac B

出版信息

Brain Res. 1985 May 27;335(1):194-9. doi: 10.1016/0006-8993(85)90294-x.

DOI:10.1016/0006-8993(85)90294-x
PMID:3873977
Abstract

Movement parameters and electromyographic (EMG) studies were carried out in two macaque monkeys performing a rapid arm movement before and after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Hypokinesia and rigidity were seen after repeated doses. Disturbances in both movements and EMG activity were similar to those reported in Parkinsonian patients.

摘要

在两只猕猴身上进行了运动参数和肌电图（EMG）研究，这两只猕猴在给予1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）前后进行快速手臂运动。重复给药后出现运动徐缓和僵硬。运动和肌电图活动的紊乱与帕金森病患者报告的情况相似。

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MPTP primate model of Parkinson's disease: a mechanographic and electromyographic study.帕金森病的MPTP灵长类动物模型：一项力学描记法和肌电图研究。
Brain Res. 1985 May 27;335(1):194-9. doi: 10.1016/0006-8993(85)90294-x.
2
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Enhanced synchrony among primary motor cortex neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease.帕金森病1-甲基-4-苯基-1,2,3,6-四氢吡啶灵长类动物模型中初级运动皮层神经元之间增强的同步性。
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The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease.1-甲基-4-苯基-1,2,3,6-四氢吡啶在动物体内作为帕金森病模型的作用。
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