帕金森病的MPTP灵长类动物模型：一项力学描记法和肌电图研究。
MPTP primate model of Parkinson's disease: a mechanographic and electromyographic study.
作者信息
Doudet D, Gross C, Lebrun-Grandie P, Bioulac B
出版信息
Brain Res. 1985 May 27;335(1):194-9. doi: 10.1016/0006-8993(85)90294-x.
PMID:3873977
Abstract
Movement parameters and electromyographic (EMG) studies were carried out in two macaque monkeys performing a rapid arm movement before and after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Hypokinesia and rigidity were seen after repeated doses. Disturbances in both movements and EMG activity were similar to those reported in Parkinsonian patients.
摘要
在两只猕猴身上进行了运动参数和肌电图（EMG）研究，这两只猕猴在给予1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）前后进行快速手臂运动。重复给药后出现运动徐缓和僵硬。运动和肌电图活动的紊乱与帕金森病患者报告的情况相似。
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