Brooks B A, Fuchs A F, Finocchio D
Brain Res. 1986 Sep 24;383(1-2):402-7. doi: 10.1016/0006-8993(86)90049-1.
Saccadic eye tracking was studied in a monkey given i.v. injections of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The Parkinson-like symptoms which appeared in the animal's general motor behavior (akinesia, bradykinesia, hypokinesia) were also observed in its eye tracking. Similar oculomotor deficits are seen in patients with idiopathic Parkinsonism. The MPTP model offers excellent possibilities for studying the mechanisms underlying the motor disabilities of Parkinson's disease.
对一只静脉注射 N-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）的猴子进行了眼球扫视跟踪研究。在动物的一般运动行为中出现的帕金森样症状（运动不能、运动迟缓、运动减退）在其眼球跟踪中也被观察到。特发性帕金森病患者也有类似的眼球运动缺陷。MPTP 模型为研究帕金森病运动障碍的潜在机制提供了极好的可能性。
