Wang Xi, Ma Li, Jiang Sheng, Wen Junping, Yan Zhaoli, Tian Long, Deng Shan, Huang Boxian, Stambler Ilia, Caruso Calogero, Min Kyung-Jin, Su Huanxing, Jin Kunlin, Mao Jiangfeng, Wu Xueyan, Han Qin, Zhao Robert Chunhua
Peking Union Medical College Hospital, Beijing, China.
Growth and Development and Gonadal Diseases Committee of Chines Aging Well Association, China.
Aging Dis. 2024 Apr 10;16(2):971-979. doi: 10.14336/AD.2024.0004.
Aging-related hypogonadism involves complex mechanisms in humans, predominantly relating to the decline of multiple hormones and senile gonads. Late-onset hypogonadism (LOH) and erectile dysfunction (ED) are the main manifestations in men, while premature ovarian insufficiency (POI) and menopause are the main forms in women. Anti-aging measures include lifestyle modification and resistance training, hormonal supplementation, stem cell therapy, metformin, and rapamycin. In this expert consensus, the mechanisms, efficacy, and side effects of stem cell therapy on aging gonadal function are reviewed. Furthermore, various methods of stem cell therapy, administered intravenously, intracavernously, and intra-ovarially, are exemplified in detail. More clinical trials on aging-related gonadal dysfunction are required to solidify the foundation of this topic.
衰老相关的性腺功能减退在人类中涉及复杂的机制，主要与多种激素水平下降和性腺衰老有关。迟发性性腺功能减退（LOH）和勃起功能障碍（ED）是男性的主要表现，而卵巢早衰（POI）和绝经是女性的主要形式。抗衰老措施包括生活方式改变和阻力训练、激素补充、干细胞疗法、二甲双胍和雷帕霉素。在本专家共识中，对干细胞疗法改善衰老性腺功能的机制、疗效和副作用进行了综述。此外，还详细举例说明了通过静脉内、海绵体内和卵巢内给药的各种干细胞治疗方法。需要更多关于衰老相关性腺功能障碍的临床试验来夯实该主题的基础。
