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英国内分泌学会女性性腺功能减退症诊治指南

Society for endocrinology guideline for understanding, diagnosing and treating female hypogonadism.

机构信息

Section of Investigative Medicine, Hammersmith Hospital, Imperial College London, London, UK.

Department of Endocrinology, Diabetes & Metabolism, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK.

出版信息

Clin Endocrinol (Oxf). 2024 Nov;101(5):409-442. doi: 10.1111/cen.15097. Epub 2024 Jun 21.

Abstract

Female hypogonadism (FH) is a relatively common endocrine disorder in women of premenopausal age, but there are significant uncertainties and wide variation in its management. Most current guidelines are monospecialty and only address premature ovarian insufficiency (POI); some allude to management in very brief and general terms, and most rely upon the extrapolation of evidence from the studies relating to physiological estrogen deficiency in postmenopausal women. The Society for Endocrinology commissioned new guidance to provide all care providers with a multidisciplinary perspective on managing patients with all forms of FH. It has been compiled using expertise from Endocrinology, Primary Care, Gynaecology and Reproductive Health practices, with contributions from expert patients and a patient support group, to help clinicians best manage FH resulting from both POI and hypothalamo-pituitary disorders, whether organic or functional.

摘要

女性性腺功能减退症(FH)是绝经前妇女中一种较为常见的内分泌疾病,但在其治疗方面存在很大的不确定性和广泛的差异。大多数现行指南都是单学科的,仅针对卵巢早衰(POI);有些则非常简略地提及了治疗方法,且大多数都是从与绝经后女性生理性雌激素缺乏相关的研究中推断而来的证据。内分泌学会委托制定了新的指南,为所有医疗保健提供者提供了一种多学科的视角,以管理所有类型的 FH 患者。该指南是利用内分泌学、初级保健、妇科和生殖健康实践方面的专业知识编写的,同时还得到了专家患者和患者支持小组的贡献,以帮助临床医生更好地管理 POI 和下丘脑-垂体疾病引起的 FH,无论其是器质性还是功能性的。

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