Chen Yonglian, Wu Jinhui
Aging Dis. 2024 Apr 7;16(2):1003-1022. doi: 10.14336/AD.2024.0407.
The proportion of the elderly population is gradually increasing as a result of medical care advances, leading to a subsequent surge in geriatric diseases that significantly impact quality of life and pose a substantial healthcare burden. Sarcopenia, characterized by age-related decline in skeletal muscle mass and quality, affects a considerable portion of older adults, particularly the elderly, and can result in adverse outcomes such as frailty, fractures, bedridden, hospitalization, and even mortality. Skeletal muscle aging is accompanied by underlying metabolic changes. Therefore, elucidating these metabolic profiles and specific mechanisms holds promise for informing prevention and treatment strategies for sarcopenia. This review provides a comprehensive overview of the key metabolites identified in current clinical studies on sarcopenia and their potential pathophysiological alterations in metabolic activity. Besides, we examine potential therapeutic strategies for sarcopenia from a perspective focused on metabolic regulation.
由于医疗保健的进步，老年人口的比例正在逐渐增加，导致老年疾病随后激增，这些疾病显著影响生活质量，并带来巨大的医疗负担。肌肉减少症的特征是骨骼肌质量和质量随年龄下降，影响相当一部分老年人，尤其是高龄老人，并可能导致诸如虚弱、骨折、卧床不起、住院甚至死亡等不良后果。骨骼肌衰老伴随着潜在的代谢变化。因此，阐明这些代谢特征和具体机制有望为肌肉减少症的预防和治疗策略提供依据。本综述全面概述了目前关于肌肉减少症的临床研究中确定的关键代谢物及其在代谢活动中的潜在病理生理改变。此外，我们从关注代谢调节的角度研究了肌肉减少症的潜在治疗策略。
