van der Gaag R, Luyendijk L, Linssen A, Kijlstra A
Clin Exp Immunol. 1985 May;60(2):311-5.
Differences in expression of HLA-B27 antigens on immune competent cells might play a role in the susceptibility to environmental factors which may be responsible for the initiation of ankylosing spondylitis (AS). Using a quantitative complement-mediated lymphocytotoxity assay we determined the expression of HLA-B27 antigens on the membranes of mononuclear cells obtained from 20 patients with AS, four patients with other seronegative arthropathies and eight healthy controls. The variation in expression of B27 between individuals was quite extensive, but there was no significant difference in the mean titration curves obtained for each of the three groups. These findings suggest that the expression of HLA-B27 antigens on the membrane of mononuclear leucocytes does not play a role in the pathogenesis of AS.
免疫活性细胞上HLA - B27抗原表达的差异可能在对环境因素的易感性中起作用,这些环境因素可能是强直性脊柱炎(AS)发病的原因。我们使用定量补体介导的淋巴细胞毒性试验,测定了从20例AS患者、4例其他血清阴性关节病患者和8名健康对照者获取的单核细胞膜上HLA - B27抗原的表达。个体之间B27表达的差异相当大,但三组中每组获得的平均滴定曲线没有显著差异。这些发现表明,单核白细胞膜上HLA - B27抗原的表达在AS的发病机制中不起作用。