Dequeker J, Decock T, Walravens M, Van de Putte I
J Rheumatol. 1978 Winter;5(4):452-9.
HLA B27 has been tested systematically in 246 patients attending a rheumatology clinic for chronic inflammatory arthritis or spondylitis. Patients were allocated to nine groups: typical ankylosing spondylitis, ankylosing spondylitis with moderate involvement without peripheral arthritis, ankylosing spondylitis with moderate involvement and with peripheral arthritis, juvenile chronic arthritis, Reiter's syndrome, Yersinia arthritis, arthropathies of inflammatory bowel disease, psoriatic arthritis, seronegative and seropositive rheumatoid arthritis. Except for seropositive rheumatoid arthritis, a significant association with HLA B27 antigen was found in all groups. In the seronegative rheumatoid arthritis group HLA B27 was present in 40% of the cases in contrast to 5.6% of the seropositive rheumatoid arthritis cases. These data confirm that a wide range of the so called "seronegative arthropathies" are associated with HLA B27 and suggest that sex and HLA B27 antigen are important factors in the manifestation of rheumatic disease. Women had less severe spondylitic changes but more peripheral arthritis of the small joints. Ankylosing spondylitis in its various forms had a comparable sex distribution despite relatively mild disease in females. The mean age of onset in the HLA B27 associated diseases was found to be significantly lower than in the seropositive rheumatoid arthritis group.
对246名因慢性炎症性关节炎或脊柱炎前往风湿病诊所就诊的患者进行了HLA B27系统检测。患者被分为九组：典型强直性脊柱炎、无外周关节炎的中度受累强直性脊柱炎、有外周关节炎的中度受累强直性脊柱炎、青少年慢性关节炎、赖特综合征、耶尔森菌关节炎、炎性肠病关节炎、银屑病关节炎、血清阴性和血清阳性类风湿关节炎。除血清阳性类风湿关节炎外，在所有组中均发现与HLA B27抗原存在显著关联。在血清阴性类风湿关节炎组中，40%的病例存在HLA B27，而血清阳性类风湿关节炎病例中这一比例为5.6%。这些数据证实，广泛的所谓“血清阴性关节病”与HLA B27相关，并表明性别和HLA B27抗原是风湿病表现的重要因素。女性的脊柱关节病变较轻，但小关节外周关节炎较多。尽管女性疾病相对较轻，但各种形式的强直性脊柱炎的性别分布相当。发现HLA B27相关疾病的平均发病年龄显著低于血清阳性类风湿关节炎组。
