Department of Ophthalmology, Capital Institute of Pediatrics Affiliated Children's Hospital, Beijing 100020, China.
Child Health Centre, Capital Institute of Pediatrics, Beijing 100020, China.
Photodiagnosis Photodyn Ther. 2024 Jun;47:104216. doi: 10.1016/j.pdpdt.2024.104216. Epub 2024 May 11.
In this study, we aimed to determine how different factors influence the effectiveness of repeated low-level red-light (RLRL) therapy in preventing and treating myopia in children.
Between June 2022 and April 2023, 336 children who visited our hospital due to myopia or significant decreases in hyperopia reserve were enrolled. The children were treated twice daily for three minutes with a head-mounted low-level red-light (single wavelength of 650 nm) therapeutic device. Each of the two treatment sessions was separated by at least four hours. The axial lengths and diopters of the children's eyes were compared before and three months after treatment, and the effects of gender, age, and baseline diopter on the efficacy of RLRL therapy were analyzed.
Following three months of treatment, the average axial length of the eyes decreased by 0.031 mm. The condition was better for the boys than for girls, but the difference was not statistically significant. As age increased (F = 8.112, P = 0.000) or as the absolute value of baseline myopia degree increased (F = 10.51, P = 0.000), axial lengths of the eyes tended to decrease. The spherical equivalent refraction (SER) of children decreased by an average of 0.012 ± 0.355D. The condition was better for the boys than for girls, but the difference was not statistically significant. SER increased in the direction of hyperopic drift as age increased (F = 2.48, P = 0.031), or as the absolute value of baseline myopia degrees increased (F = 6.835, P = 0.000). There were no obvious side effects following the treatment.
This study showed that RLRL therapy is a potential efficient, easily operable, and practically feasible method for the prevention and control of myopia.
本研究旨在探讨不同因素对重复低水平红光（RLRL）疗法预防和治疗儿童近视的效果的影响。
2022 年 6 月至 2023 年 4 月期间，我院因近视或远视储备显著下降而就诊的 336 名儿童被纳入研究。儿童使用头戴式低水平红光（单一波长 650nm）治疗设备，每天治疗两次，每次 3 分钟。两次治疗之间至少间隔四小时。治疗前和治疗后三个月比较儿童眼球的眼轴长度和屈光度，并分析性别、年龄和基线屈光度对 RLRL 治疗效果的影响。
治疗三个月后，眼轴平均长度减少 0.031mm。男孩的情况好于女孩，但差异无统计学意义。随着年龄的增长（F=8.112，P=0.000）或基线近视度数绝对值的增加（F=10.51，P=0.000），眼轴长度趋于缩短。儿童的球镜等效屈光度（SER）平均降低 0.012±0.355D。男孩的情况好于女孩，但差异无统计学意义。随着年龄的增长（F=2.48，P=0.031）或基线近视度数绝对值的增加（F=6.835，P=0.000），SER 朝着远视漂移的方向增加。治疗后无明显不良反应。
本研究表明，RLRL 疗法是一种预防和控制近视的有效、易操作、实用的方法。
