Kang Daohuan, Yuan Lu, Feng Jia, Yu Rui, Grzybowski Andrzej, Jin Kai, Sun Wen
Department of Ophthalmology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, Poland.
BMC Ophthalmol. 2025 May 7;25(1):273. doi: 10.1186/s12886-025-04109-5.
This study aimed to investigate the effects of Repeated Low-Level Red Light (RLRL) therapy on axial length (AL) in myopic individuals and to identify key predictors for a good response to the treatment, with a focus on baseline ocular characteristics and treatment compliance.
A total of 91 participants were enrolled, with 50 classified in the poor responders' group and 41 in the good responders' group. Baseline characteristics, including age, gender, pupil constriction diameter (PCD), intraocular pressure (IOP), spherical equivalent refraction (SER), AL, corneal curvature (ACC), and choroidal thickness (CT) were recorded. Compliance and AL changes were tracked over one year. Univariable and multivariable analyses identified factors associated with AL changes.
Good responders' group showed a significant AL reduction (-0.29 ± 0.16 mm, p < 0.001), while poor responders' group had an increase (+ 0.23 ± 0.12 mm, p < 0.001). Good responders' group had lower initial SER (-4.15 ± 2.87 D vs. -2.62 ± 1.80 D, p = 0.004) and longer AL (24.76 ± 1.21 mm vs. 24.15 ± 0.99 mm, p = 0.010). Both groups showed CT changes (p < 0.001), with greater increases in good responders. Univariable analysis identified initial AL and SER as predictors of a good response (both p < 0.001). Compliance showed a trend toward significance in multivariable analysis (β = -0.196, p = 0.052).
Longer baseline AL and lower SER are key predictors of a good response to RLRL therapy. Moreover, treatment compliance showed a trend toward significance, emphasizing its crucial role in achieving optimal outcomes.
本研究旨在探讨重复低强度红光（RLRL）疗法对近视患者眼轴长度（AL）的影响，并确定治疗良好反应的关键预测因素，重点关注基线眼部特征和治疗依从性。
共纳入91名参与者，其中50名归类为反应不佳组，41名归类为反应良好组。记录基线特征，包括年龄、性别、瞳孔收缩直径（PCD）、眼压（IOP）、等效球镜度（SER）、AL、角膜曲率（ACC）和脉络膜厚度（CT）。随访一年，跟踪依从性和AL变化。单变量和多变量分析确定与AL变化相关的因素。
反应良好组的AL显著降低（-0.29±0.16mm，p<0.001），而反应不佳组则增加（+0.23±0.12mm，p<0.001）。反应良好组的初始SER较低（-4.15±2.87D对-2.62±1.80D，p=0.004），AL较长（24.76±1.21mm对24.15±0.99mm，p=0.010）。两组均显示CT变化（p<0.001），反应良好组的增加幅度更大。单变量分析确定初始AL和SER是良好反应的预测因素（均p<0.001）。在多变量分析中，依从性显示出显著趋势（β=-0.196，p=0.052）。
较长的基线AL和较低的SER是对RLRL疗法良好反应 的关键预测因素。此外，治疗依从性显示出显著趋势，强调了其在实现最佳结果中的关键作用。
