Department of Neurosurgery, Hôpital Privé Clairval - Ramsay Santé, 317 Bd de Redon, 13009, Marseille, France.
Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 34295, Montpellier cedex 5, France.
Acta Neurochir (Wien). 2024 May 14;166(1):214. doi: 10.1007/s00701-024-06093-z.
Meningioma is one of the most common neoplasm of the central nervous system. To describe the epidemiology of meningioma operated in France and, to assess grading and histopathological variability among the different neurosurgical centres.
We processed the French Brain Tumour Database (FBTDB) to conduct a nationwide population-based study of all histopathologically confirmed meningiomas between 2006 and 2015.
30,223 meningiomas cases were operated on 28,424 patients, in 61 centres. The average number of meningioma operated per year in France was 3,022 (SD ± 122). Meningioma was 3 times more common in women (74.1% vs. 25.9%). The incidence of meningioma increased with age and, mean age at surgery was 58.5 ± 13.9 years. Grade 1, 2, and 3 meningiomas accounted for 83.9%, 13.91% and, 2.19% respectively. There was a significant variability of meningioma grading by institutions, especially for grade 2 which spanned from 5.1% up to 22.4% (p < 0.001). Moreover, the proportion of grade 2 significantly grew over the study period (p < 0.001). There was also a significant variation in grade 1 subtypes diagnosis among the institutions (p < 0.001). 89.05% of the patients had solely one meningioma surgery, 8.52% two and, 2.43% three or more. The number of surgeries was associated to the grade of malignancy (p < 0.001).
The incidence of meningioma surgery increased with age and, peaked at 58.5 years. They were predominantly benign with meningothelial subtype being the most common. However, there was a significant variation of grade 1 subtypes diagnosis among the centres involved. The proportion of grade 2 meningioma significantly grew over the study time, on contrary to malignant meningioma proportion, which remained rare and, stable over time around 2%. Likewise, there was a significant variability of grade 2 meningioma rate among the institutions.
脑膜瘤是中枢神经系统最常见的肿瘤之一。本研究旨在描述法国脑膜瘤的流行病学特征，并评估不同神经外科中心的分级和组织病理学变异性。
我们对法国脑肿瘤数据库（FBTDB）进行了处理，对 2006 年至 2015 年间所有经组织病理学证实的脑膜瘤进行了全国范围内的基于人群的研究。
在 61 个中心共对 28424 例患者的 30223 例脑膜瘤病例进行了手术。法国每年平均手术切除的脑膜瘤数量为 3022 例（标准差±122）。女性脑膜瘤的发病率是男性的 3 倍（74.1% vs. 25.9%）。脑膜瘤的发病率随年龄增长而增加，手术时的平均年龄为 58.5±13.9 岁。1 级、2 级和 3 级脑膜瘤分别占 83.9%、13.91%和 2.19%。不同机构的脑膜瘤分级存在显著差异，特别是 2 级脑膜瘤，从 5.1%到 22.4%不等（p<0.001）。此外，在研究期间，2 级脑膜瘤的比例显著增加（p<0.001）。不同机构诊断的 1 级亚型也存在显著差异（p<0.001）。89.05%的患者仅进行了一次脑膜瘤手术，8.52%的患者进行了两次手术，2.43%的患者进行了三次或更多次手术。手术次数与恶性程度相关（p<0.001）。
脑膜瘤手术的发病率随年龄增长而增加，在 58.5 岁时达到高峰。脑膜瘤主要为良性，脑膜上皮型最常见。然而，不同中心之间 1 级亚型的诊断存在显著差异。2 级脑膜瘤的比例在研究期间显著增加，而恶性脑膜瘤的比例则相对较少且保持稳定，约为 2%。同样，不同机构的 2 级脑膜瘤发生率也存在显著差异。
