Department of Oncology, Tianjin Union Medical Center, Nankai University, No.190 Jieyuan Road, Hongqiao District, Tianjin, 300121, P. R. China.
Department of Oncology, People's Hospital of Rongcheng, Shandong, Rongcheng, P. R. China.
BMC Cancer. 2024 May 13;24(1):582. doi: 10.1186/s12885-024-12339-x.
Local recurrence after surgery and radiochemotherapy seriously affects the prognosis of locally advanced rectal cancer (LARC) patients. Studies on molecular markers related to the radiochemotherapy sensitivity of cancers have been widely carried out, which might provide valued information for clinicians to carry out individual treatment.
To find potential biomarkers of tumors for predicting postoperative recurrence.
In this study, LARC patients undergoing surgery and concurrent radiochemotherapy were enrolled. We focused on clinicopathological factors and PTEN, SIRT1, p-4E-BP1, and pS6 protein expression assessed by immunohistochemistry in 73 rectal cancer patients with local recurrence and 76 patients without local recurrence.
The expression of PTEN was higher, while the expression of p-4E-BP1 was lower in patients without local recurrence than in patients with local recurrence. Moreover, TNM stage, lymphatic vessel invasion (LVI), PTEN and p-4E-BP1 might be independent risk factors for local recurrence after LARC surgery combined with concurrent radiochemotherapy.
This study suggests that PTEN and p-4E-BP1 might be potential biomarkers for prognostic prediction and therapeutic targets for LARC.
手术和放化疗后局部复发严重影响局部晚期直肠癌（LARC）患者的预后。目前已经广泛开展了与癌症放化疗敏感性相关的分子标志物研究，这可能为临床医生开展个体化治疗提供有价值的信息。
寻找预测术后复发的肿瘤潜在标志物。
本研究纳入了接受手术和同步放化疗的 LARC 患者。我们主要关注了 73 例局部复发和 76 例无局部复发的直肠癌患者的临床病理因素和免疫组织化学评估的 PTEN、SIRT1、p-4E-BP1 和 pS6 蛋白表达。
无局部复发患者的 PTEN 表达较高，而 p-4E-BP1 的表达较低。此外，TNM 分期、淋巴管浸润（LVI）、PTEN 和 p-4E-BP1 可能是 LARC 手术联合同步放化疗后局部复发的独立危险因素。
本研究表明，PTEN 和 p-4E-BP1 可能是 LARC 预后预测的潜在生物标志物和治疗靶点。
