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磷酸化4E结合蛋白1的过表达预示着中国肝门部胆管癌患者的淋巴结转移及不良预后。

Overexpression of phosphorylated 4E-binding protein 1 predicts lymph node metastasis and poor prognosis of Chinese patients with hilar cholangiocarcinoma.

作者信息

Fang Zheng, Lu Lei, Tian Zhiqiang, Luo Kunlun

机构信息

Department of General Surgery, 101st Hospital of People's Liberation Army, Wuxi, Jiangsu, China,

出版信息

Med Oncol. 2014 May;31(5):940. doi: 10.1007/s12032-014-0940-5. Epub 2014 Apr 6.

DOI:10.1007/s12032-014-0940-5
PMID:24706262
Abstract

Previous studies have confirmed the role of phosphorylated form of 4E-binding protein 1 (p-4E-BP1) as a good candidate tumor biomarker. The aim of this study was to investigate p-4E-BP1 expression status in hilar cholangiocarcinoma (HCCA) specimens and to clarify its clinical significance. Tissue microarray containing tumor specimens obtained from 61 patients with HCCA were constructed. p-4E-BP1 was investigated by immunohistochemical studies. High/moderate expression p-4E-BP1 was observed in 57.4% (35/61) primary cancer specimens. Overexpression of p-4E-BP1 protein was associated with poor differentiation and regional lymph node metastasis. Survival analysis and Cox proportional hazards model revealed that p-4E-BP1 overexpression was an independent factor in predicting recurrence-free survival and overall survival for HCCA patients, apart from tumor invasion and complete resection. P-4E-BP1 was highly expressed in HCCA. Overexpressed p-4E-BP1 might be a novel biomarker to predict the clinical outcome of patients with resected HCCA.

摘要

以往研究已证实4E结合蛋白1的磷酸化形式（p-4E-BP1）作为一种良好的候选肿瘤生物标志物的作用。本研究旨在调查肝门部胆管癌（HCCA）标本中p-4E-BP1的表达状况，并阐明其临床意义。构建了包含61例HCCA患者肿瘤标本的组织芯片。通过免疫组织化学研究检测p-4E-BP1。在57.4%（35/61）的原发性癌标本中观察到p-4E-BP1高/中度表达。p-4E-BP1蛋白的过表达与低分化和区域淋巴结转移相关。生存分析和Cox比例风险模型显示，除肿瘤侵犯和完整切除外，p-4E-BP1过表达是预测HCCA患者无复发生存和总生存的独立因素。P-4E-BP1在HCCA中高表达。过表达的p-4E-BP1可能是预测切除的HCCA患者临床结局的一种新型生物标志物。

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