Singh Anoop Kumar, Kumari Gayatri, Tangri Rajiv
Department of Neurosurgery, Lifeline Hospital and Research Center, Azamgarh, Uttar Pradesh, India.
Department of Pathology, Dr Lal path Labs, National Reference Laboratory, New Delhi, Delhi, India.
Surg Neurol Int. 2024 Apr 12;15:129. doi: 10.25259/SNI_150_2024. eCollection 2024.
Giant prolactinomas are rare; among them, the amyloidogenic variant, prolactinomas with extensive spherical amyloid deposits, are rare, with only 30 cases reported with recommendations of surgical management contrary to the routine prolactinoma's medical management.
We report here a case of giant amyloidogenic prolactinoma in a 32-year-old male patient who had a very atypical presentation in terms of clinical, radiological, and pathological features and responded to dopamine agonist therapy like a normal prolactinoma.
Amyloidogenic giant prolactinomas are rare. Contrary to usual belief, even they remain medically responsive; however, more literature is required to decide their ideal management.
巨大泌乳素瘤较为罕见；其中，具有淀粉样变性的变异型，即伴有广泛球形淀粉样沉积物的泌乳素瘤，更是罕见，仅有30例报道，其手术治疗建议与常规泌乳素瘤的药物治疗相反。
我们在此报告一例32岁男性患者的巨大淀粉样变性泌乳素瘤病例，该病例在临床、影像学和病理学特征方面具有非常不典型的表现，并且对多巴胺激动剂治疗的反应与正常泌乳素瘤相同。
淀粉样变性巨大泌乳素瘤罕见。与通常的看法相反，即使是这类肿瘤对药物治疗仍有反应；然而，需要更多文献来确定其理想的治疗方法。
