Chen Jinyue, Wang Nanfang, Qi Chaofan, Chang Junbiao, Wang Xiao-Na
Pingyuan Laboratory, State Key Laboratory of Antiviral Drugs, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China.
Org Biomol Chem. 2024 May 29;22(21):4264-4268. doi: 10.1039/d4ob00470a.
Herein, we describe a novel metal-free Brønsted acid-catalyzed Ficini [2 + 2] cycloaddition of ynamides with enones under mild reaction conditions, leading to the formation of various cyclobutenamides in generally good to excellent yields within short reaction times. This work represents the first example of ynamides involved in a nonmetal-catalyzed [2 + 2] cycloaddition with enones.
