Department of General Surgery, The First Affiliated Hospital of Harbin Medical, University, Harbin 150001, China.
Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Aging (Albany NY). 2024 May 13;16(10):8572-8584. doi: 10.18632/aging.205825.
The interleukin (IL) plays a role in the development of acute pancreatitis (AP). However, the specific IL in AP has not been fully revealed. Therefore, the association between prospective IL and AP was studied via Mendelian randomization (MR).
The HUGO Gene nomenclature committee (HGNC) database provided 47 interleukin related genes (ILRGs). ILRGs and differentially expressed genes (DEGs) from GSE194331 were overlapped to create differently expressed ILRGs (DE-ILRGs). The integrative epidemiology unit (IEU) open genome-wide association study (GWAS) database provided exposure and outcome datasets. Univariate MR (UVMR) analysis using MR-Egger, IVW, simple mode, and weighted mode was done. UVMR results were verified using sensitivity analysis. Drug prediction, MVMR analysis, and PPI network development were also performed.
Six DE-ILRGs were obtained. IL27 and IL1RN were substantially causally linked with AP by UVMR analysis (OR = 0.926, P < 0.001 and OR = 1.031, P = 0.023). Our sensitivity analysis showed the dependability of our results. Direct effect of IL27 was suggested by MVMR analysis. In the cytokine receptor binding pathway, IL27 and IL1RN interacted with IL36G and IL1R2. TAE-684, ARQ-680, and 12 other IL1RN and 14 IL27 medications were predicted.
IL1RN was identified as a risk factor for acute pancreatitis (AP), but IL27 was found to be a protective factor for AP.
白细胞介素 (IL) 在急性胰腺炎 (AP) 的发展中起作用。然而，AP 中具体的 IL 尚未完全揭示。因此，通过孟德尔随机化 (MR) 研究了前瞻性 IL 与 AP 之间的关联。
HUGO 基因命名委员会 (HGNC) 数据库提供了 47 个白细胞介素相关基因 (ILRG)。ILRG 和 GSE194331 中的差异表达基因 (DEG) 重叠以创建差异表达的 ILRG (DE-ILRG)。整合流行病学单位 (IEU) 开放全基因组关联研究 (GWAS) 数据库提供了暴露和结局数据集。使用 MR-Egger、IVW、简单模式和加权模式进行了单变量 MR (UVMR) 分析。使用敏感性分析验证了 UVMR 结果。还进行了药物预测、MVMR 分析和 PPI 网络开发。
获得了 6 个 DE-ILRG。UVMR 分析表明 IL27 和 IL1RN 与 AP 具有实质性的因果关系（OR = 0.926，P < 0.001 和 OR = 1.031，P = 0.023）。我们的敏感性分析表明我们的结果是可靠的。MVMR 分析表明 IL27 具有直接作用。在细胞因子受体结合途径中，IL27 和 IL1RN 与 IL36G 和 IL1R2 相互作用。预测了 TAE-684、ARQ-680 和其他 12 种 IL1RN 和 14 种 IL27 药物。
IL1RN 被确定为急性胰腺炎 (AP) 的危险因素，而 IL27 被发现是 AP 的保护因素。
