Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Infection and Liver Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Front Immunol. 2024 Aug 15;15:1420840. doi: 10.3389/fimmu.2024.1420840. eCollection 2024.
To date, the association between glucocorticoid use and the risk of pancreatitis remains controversial. The aim of this study was the investigation of this possible relationship.
We carried out a two-sample Mendelian randomization (MR) analysis using GWAS data from European ancestry, East Asian descendants and the FinnGen Biobank Consortium to evaluate this potential causal relationship. Genetic variants associated with glucocorticoid use were selected based on genome-wide significance (p < 5×10-8).
Our MR analysis of European ancestry data revealed no significant causal relationship between glucocorticoid use and AP (IVW: OR=1.084, 95% CI= 0.945-1.242, P=0.249; MR-Egger: OR=1.049, 95% CI= 0.686-1.603, P=0.828; weighted median: OR=1.026, 95% CI= 0.863-1.219, P=0.775) or CP (IVW: OR=1.027, 95% CI= 0.850-1.240, P=0.785; MR-Egger: OR= 1.625, 95% CI= 0.913-2.890, P= 0.111; weighted median: OR= 1.176, 95% CI= 0.909-1.523, P= 0.218). Sensitivity analyses, including MR-Egger and MR-PRESSO, indicated no evidence of pleiotropy or heterogeneity, confirming the robustness of our findings. Multivariable MR analysis adjusted for alcohol consumption, BMI, cholelithiasis and C-reactive protein levels supported these findings. Replicated analysis was performed on datasets from the FinnGen Biobank Consortium and East Asian descendants, and similar results were obtained.
This MR analysis suggests that there is no causal association between glucocorticoid use and the risk of pancreatitis.
迄今为止，糖皮质激素的使用与胰腺炎风险之间的关联仍存在争议。本研究旨在探讨这种潜在的关系。
我们使用欧洲血统、东亚后裔和芬兰基因生物银行联盟的 GWAS 数据进行了两样本孟德尔随机化 (MR) 分析，以评估这种潜在的因果关系。根据全基因组显著性 (p < 5×10-8) 选择与糖皮质激素使用相关的遗传变异。
我们对欧洲血统数据的 MR 分析显示，糖皮质激素的使用与 AP（IVW：OR=1.084，95%CI=0.945-1.242，P=0.249；MR-Egger：OR=1.049，95%CI=0.686-1.603，P=0.828；加权中位数：OR=1.026，95%CI=0.863-1.219，P=0.775）或 CP（IVW：OR=1.027，95%CI=0.850-1.240，P=0.785；MR-Egger：OR=1.625，95%CI=0.913-2.890，P=0.111；加权中位数：OR=1.176，95%CI=0.909-1.523，P=0.218）之间不存在因果关系。包括 MR-Egger 和 MR-PRESSO 的敏感性分析表明，不存在多效性或异质性的证据，证实了我们研究结果的稳健性。多变量 MR 分析调整了酒精摄入、BMI、胆石症和 C 反应蛋白水平，支持了这些发现。在芬兰基因生物银行联盟和东亚后裔的数据集上进行了复制分析，得到了类似的结果。
这项 MR 分析表明，糖皮质激素的使用与胰腺炎风险之间没有因果关系。
