Department of Chemistry, Government College of Engineering, Keonjhar, Odisha, India.
School of Biotechnology, Campus-11, KIIT Deemed-to-be-University, Bhubaneswar, Odisha, India.
Rev Med Virol. 2024 May;34(3):e2541. doi: 10.1002/rmv.2541.
As the mankind counters the ongoing COVID-19 pandemic by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), it simultaneously witnesses the emergence of mpox virus (MPXV) that signals at global spread and could potentially lead to another pandemic. Although MPXV has existed for more than 50 years now with most of the human cases being reported from the endemic West and Central African regions, the disease is recently being reported in non-endemic regions too that affect more than 50 countries. Controlling the spread of MPXV is important due to its potential danger of a global spread, causing severe morbidity and mortality. The article highlights the transmission dynamics, zoonosis potential, complication and mitigation strategies for MPXV infection, and concludes with suggested 'one health' approach for better management, control and prevention. Bibliometric analyses of the data extend the understanding and provide leads on the research trends, the global spread, and the need to revamp the critical research and healthcare interventions. Globally published mpox-related literature does not align well with endemic areas/regions of occurrence which should ideally have been the scenario. Such demographic and geographic gaps between the location of the research work and the endemic epicentres of the disease need to be bridged for greater and effective translation of the research outputs to pubic healthcare systems, it is suggested.
随着人类正在用新型严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)来应对当前的 COVID-19 大流行,我们同时也见证了猴痘病毒(MPXV)的出现,该病毒在全球范围内传播,并有可能引发另一场大流行。尽管 MPXV 已经存在了超过 50 年,大多数人类病例都报告自流行于西非和中非地区,但该疾病最近也在非流行地区报告,影响了超过 50 个国家。由于其潜在的全球传播危险,导致严重的发病率和死亡率,因此控制 MPXV 的传播很重要。本文重点介绍了 MPXV 的传播动力学、人畜共患潜力、并发症和缓解策略,并以建议的“同一健康”方法来更好地管理、控制和预防疾病。对数据的文献计量学分析扩展了对研究趋势、全球传播以及更新关键研究和医疗保健干预措施的理解和认识。全球发表的有关猴痘的文献与疾病发生的流行地区/区域并不相符,而理想情况下,这种研究工作的地点和疾病流行中心之间的人口和地理差距应该得到弥合,以便将研究成果更有效地转化为公共卫生保健系统,人们提出了这样的建议。