糙面内质网中离子转运的肌醇三磷酸修饰
Inositol trisphosphate modification of ion transport in rough endoplasmic reticulum.
作者信息
Muallem S, Schoeffield M, Pandol S, Sachs G
出版信息
Proc Natl Acad Sci U S A. 1985 Jul;82(13):4433-7. doi: 10.1073/pnas.82.13.4433.
Abstract
The ion transport properties of the rough endoplasmic reticulum (RER) from liver have been defined by using measurements of active and potential gradient-driven transport. The Ca2+ pump is shown to be electrogenic, and both ATP and potential difference is able to drive vanadate-inhibitable Ca2+ uptake into the RER. ATP-dependent Ca2+ transport into the RER depends on the presence of tetraethylammonium-sensitive cation conductance and a furosemide-inhibited cation/chloride cotransport pathway. Inositol trisphosphate does not affect either of the monovalent ion translocation systems but activates a Ca2+ conductance in the RER, allowing efflux of RER Ca2+ stores into the cytosol in exchange for K+ uptake.
摘要
通过对主动转运和电位梯度驱动转运的测量，已确定了肝脏粗面内质网（RER）的离子转运特性。Ca2+泵表现出电生性，ATP和电位差都能够驱动钒酸盐抑制的Ca2+摄取进入RER。依赖ATP的Ca2+转运进入RER取决于四乙铵敏感的阳离子电导和速尿抑制的阳离子/氯离子共转运途径的存在。肌醇三磷酸不影响任何一种单价离子转运系统，但可激活RER中的Ca2+电导，使RER中的Ca2+储存外流至细胞质中，以交换摄取K+。
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