Galloway M J, Mackie M J, McVerry B A
Thromb Res. 1985 May 15;38(4):311-20. doi: 10.1016/0049-3848(85)90131-8.
30 consecutive patients with acute leukaemia were studied prior to commencement of treatment in order to assess the incidence and significance of raised elastase (ELP) - alpha 1 antitrypsin complex level. In addition the reliability of detecting low factor XIII subunit levels as an indicator of in vivo release of ELP was evaluated. While 15 patients had raised levels of ELP alpha 1 antitrypsin complex levels, only 4 of these had reduced levels or factor XIII subunits A and S. In addition increased levels of ELP- alpha 1 antitrypsin complex were not associated with any marked disturbance of routine coagulation tests. Patients with raised ELP- alpha 1 antitrypsin complex levels had significantly higher circulating white cell and blast cell counts as compared to those patients with normal levels of this complex. In patients entering remission the levels of ELP- alpha 1 antitrypsin complex returned to normal.
为了评估弹性蛋白酶（ELP）-α1抗胰蛋白酶复合物水平升高的发生率及意义，在治疗开始前对30例急性白血病患者进行了研究。此外，还评估了检测低因子XIII亚基水平作为ELP体内释放指标的可靠性。虽然15例患者的ELP-α1抗胰蛋白酶复合物水平升高，但其中只有4例的因子XIII亚基A和S水平降低。此外，ELP-α1抗胰蛋白酶复合物水平升高与常规凝血试验的任何明显异常均无关联。与该复合物水平正常的患者相比，ELP-α1抗胰蛋白酶复合物水平升高的患者循环白细胞和原始细胞计数显著更高。进入缓解期的患者中，ELP-α1抗胰蛋白酶复合物水平恢复正常。
