Key Laboratory of Basic and Application Research of Beiyao, (Ministry of Education), Heilongjiang University of Chinese Medicine, 150040, Harbin, China.
Chem Biodivers. 2024 Aug;21(8):e202400494. doi: 10.1002/cbdv.202400494. Epub 2024 Jul 3.
Genus Buxus plants, commonly known as "boxwood", are widely distributed in China. The stems, branches, and leaves of the plant are traditionally used for rheumatism, toothache, chest pain, abdominal gas, and other diseases. However, an overview of the genus Buxus remains to be provided.
To provide a scientific basis for the appropriate use and further research the recent advancements in the traditional usage, phytochemistry, and, pharmacology of Buxus.
Chemical composition and pharmacological correlation studies through a literature review.
Between 1970 and 2023, the available data concerning Buxus was compiled from online scientific sources, such as Sci-Finder, PubMed, CNKI, Google Scholar, and the Chinese Pharmacopoeia. Plant names were verified from "The Plant List" (http://www.theplantlist.org/).
To date, 266 structurally diverse chemicals have been extracted and identified from the genus Buxus. Alkaloids constitute one of its primary bioactive phytochemicals. A summary of the channels of action of Cyclovirobuxine D on the cytotoxicity of a variety of cancers has been provided.
Numerous findings from contemporary phytochemical and pharmacological studies support the traditional use, facilitating its application. Further research is necessary to address various shortcomings, including the identification of the active ingredients and quality control of the genus Buxus.
黄杨属植物，俗称“黄杨木”，在中国广泛分布。该植物的茎、枝和叶传统上用于治疗风湿、牙痛、胸痛、腹胀、气等疾病。然而，对黄杨属植物的综述仍然存在。
为黄杨属植物的合理使用提供科学依据，并进一步研究其传统用途、植物化学和药理学的最新进展。
通过文献回顾进行化学成分和药理相关性研究。
在 1970 年至 2023 年期间，从在线科学资源（如 SciFinder、PubMed、CNKI、Google Scholar 和《中国药典》）中编译了有关黄杨属植物的可用数据。植物名称通过“植物名录”（http://www.theplantlist.org/）进行验证。
迄今为止，已从黄杨属植物中提取并鉴定出 266 种结构多样的化学物质。生物碱是其主要生物活性植物化学物质之一。本文总结了环维黄杨星 D 对多种癌症的细胞毒性的作用途径。
当代植物化学和药理学研究的众多发现支持了其传统用途，为其应用提供了依据。需要进一步研究来解决各种缺点，包括鉴定有效成分和控制黄杨属植物的质量。
