School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Department of Laboratory Medicine, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, China.
Phytomedicine. 2024 Dec;135:156008. doi: 10.1016/j.phymed.2024.156008. Epub 2024 Sep 6.
Sarcandra is one of the five genera of Chloranthaceae, which has a long history of medicinal use and high medicinal value, with excellent therapeutic effects on liver cancer, pneumonia, colitis, bone fractures, and dysentery. Among its species, Sarcandra glabra (Thunb.) Nakai has been extensively utilized in diverse compound formulations, toothpaste, tea, daily commodities, as well as health supplements. Therefore, in terms of its medicinal properties and effectiveness, the genus has considerable potential for development and utilization.
This paper presents a systematic review of the botany, ethnomedicine, phytochemistry, pharmacology, and toxicology of Sarcandra plants, aiming to deepen our understanding of Sarcandra properties further, to provide a reference for the rational utilization of Sarcandra plant resources, and at the same time laying a foundation for the development of new medicines and the study of natural products.
In this paper, we collected information about Sarcandra species through PubMed, Science Direct, Web of Science, Baidu Scholar, Google Scholar, CNKI, and other databases using the keywords Sarcandra, botany, traditional uses, chemical compounds, pharmacology and toxicology. Its botanical-related information was obtained through the Flora of China (www.iplant.cn).
Three species of Sarcandra plants worldwide are distributed from eastern Asia to India. This genus has a long history of medicinal uses, high medicinal value, and a wide range of applications. At present, 462 compounds have been isolated and identified from Sarcandra plants, and their diversity contributes to the diversity of the pharmacological effects of Sarcandra plants. Numerous studies have shown that Sarcandra plants exhibit significant antitumor, antibacterial, anti-inflammatory, antimalarial, antiviral, antithrombocytopenia, immunomodulatory, antioxidant, hepatoprotective, hypoglycemic and hypolipidemic effects, with low toxicity and side effects. However, most studies have focused on Sarcandra glabra (Thunb.) Nakai and studies on other plants of the genus have yet to be explored.
Sarcandra plants have a wide range of clinical uses and diverse chemical compounds. However, the main research has been concentrated on Sarcandra glabra (Thunb.) Nakai, and future research should explore the medicinal properties of other Sarcandra plants to expand their potential clinical applications. Meanwhile, the pharmacological activities of compounds from Sarcandra species need to be studied in greater depth and detail to provide an appropriate scientific basis for developing new drugs and natural product research.
金粟兰科金粟兰属是金粟兰科的五个属之一，具有悠久的药用历史和较高的药用价值，对肝癌、肺炎、结肠炎、骨折和痢疾有极好的治疗效果。在其物种中，草珊瑚（Thunb.）Nakai 已广泛应用于各种复方制剂、牙膏、茶、日用品以及保健品中。因此，就其药用特性和功效而言，该属具有相当大的开发利用潜力。
本文对金粟兰属植物的植物学、民族医学、植物化学、药理学和毒理学进行了系统综述，旨在进一步加深对金粟兰属植物特性的认识，为金粟兰属植物资源的合理利用提供参考，同时为新药的开发和天然产物的研究奠定基础。
本文通过PubMed、Science Direct、Web of Science、百度学术、Google Scholar、CNKI 等数据库，以金粟兰、植物学、传统用途、化学化合物、药理学和毒理学等关键词，收集了有关金粟兰属植物的信息。通过《中国植物志》（www.iplant.cn）获得了与植物学相关的信息。
全世界有三种金粟兰属植物分布于东亚至印度。该属药用历史悠久，药用价值高，应用广泛。目前，已从金粟兰属植物中分离鉴定出 462 种化合物，其多样性导致了金粟兰属植物药理作用的多样性。大量研究表明，金粟兰属植物具有显著的抗肿瘤、抗菌、抗炎、抗疟、抗病毒、抗血小板减少、免疫调节、抗氧化、保肝、降血糖、降血脂作用，且毒性和副作用低。然而，大多数研究都集中在草珊瑚（Thunb.）Nakai 上，对该属其他植物的研究尚未开展。
金粟兰属植物具有广泛的临床用途和多样的化学物质。然而，主要的研究集中在草珊瑚（Thunb.）Nakai 上，未来的研究应该探索其他金粟兰属植物的药用特性，以扩大其潜在的临床应用。同时，需要更深入和详细地研究金粟兰属植物化合物的药理活性，为开发新药和天然产物研究提供适当的科学依据。
