Graduate School of Health, University of Technology Sydney, PO Box 123, Sydney, NSW, 2007, Australia.
Arch Osteoporos. 2024 May 14;19(1):37. doi: 10.1007/s11657-024-01401-7.
Osteoporosis is a common but sub-optimally managed disease amongst aged care residents. Pharmacists undertaking comprehensive medication reviews is one strategy to improve osteoporosis management. Analysis of pharmacist medication review recommendations has identified common clinical practice issues that can be addressed to optimise osteoporosis management for aged care residents.
This study investigates the prevalence of osteoporosis medicine use amongst Australian aged care residents and explores drug-related problems (DRPs) identified during medication reviews and pharmacist recommendations to resolve them.
Resident demographics, medications, diagnoses, osteoporosis related DRPs, and recommendations to resolve them were extracted from medication review reports. A mixed methods approach was taken to analysis, involving descriptive statistical analysis and content analysis.
Medication review reports relating to 980 residents were collected. Antiresorptive therapies were used by 21.7% of residents, of which 87.2% were prescribed denosumab. Osteoporosis related DRPs represented 14.0% of all DRPs identified by pharmacists. Vitamin D was involved in 55.4% of these DRPs, the remainder concerned antiresorptive therapies (23.4%), medications contributing to osteoporosis (16.3%), and calcium (4.9%). Frequent deviations in practice from aged care clinical guidelines and consensus recommendations concerning vitamin D and calcium were found. DRPs and accompanying recommendations relating to denosumab revealed inadequate monitoring and inadvertent therapy disruptions.
Pharmacist identified DRPs and recommendations revealed common aspects of clinical practice that can be addressed to improve osteoporosis management for aged care residents. A need to raise awareness of aged care-specific consensus recommendations concerning vitamin D and calcium is evident. Facility protocols and procedures must be developed and implemented to ensure safe and effective use of denosumab.
本研究调查了澳大利亚老年护理居民中骨质疏松症药物使用的流行情况,并探讨了药物审查期间发现的与药物相关的问题 (DRP) 以及解决这些问题的药剂师建议。
从药物审查报告中提取居民人口统计学、药物、诊断、与骨质疏松症相关的 DRP 以及解决这些问题的建议。采用混合方法进行分析,包括描述性统计分析和内容分析。
共收集了 980 名居民的药物审查报告。抗吸收疗法在 21.7%的居民中使用,其中 87.2%的居民开了地舒单抗。骨质疏松症相关的 DRP 占药剂师发现的所有 DRP 的 14.0%。维生素 D 涉及其中 55.4%的 DRP,其余与抗吸收疗法 (23.4%)、导致骨质疏松症的药物 (16.3%)和钙 (4.9%)有关。经常发现维生素 D 和钙方面的实践与老年护理临床指南和共识建议存在偏差。与地舒单抗相关的 DRP 和伴随的建议表明,监测不足和无意中中断治疗。
药剂师确定的 DRP 和建议揭示了可以解决的常见临床实践方面,以改善老年护理居民的骨质疏松症管理。显然需要提高对维生素 D 和钙的老年护理特定共识建议的认识。必须制定和实施设施协议和程序,以确保地舒单抗的安全有效使用。