Department of microbiology and immunology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, China.
Faculty of Life science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Cell Commun Signal. 2024 May 14;22(1):268. doi: 10.1186/s12964-024-01611-z.
Ulcerative colitis (UC) is increasingly common, and it is gradually become a kind of global epidemic. UC is a type of inflammatory bowel disease (IBD), and it is a lifetime recurrent disease. UC as a common disease has become a financial burden for many people and has the potential to develop into cancer if not prevented or treated. There are multiple factors such as genetic factors, host immune system disorders, and environmental factors to cause UC. A growing body of research have suggested that intestinal microbiota as an environmental factor play an important role in the occurrence and development of UC. Meanwhile, evidence to date suggests that manipulating the gut microbiome may represent effective treatment for the prevention or management of UC. In addition, the main clinical drugs to treat UC are amino salicylate and corticosteroid. These clinical drugs always have some side effects and low success rate when treating patients with UC. Therefore, there is an urgent need for safe and efficient methods to treat UC. Based on this, probiotics and prebiotics may be a valuable treatment for UC. In order to promote the wide clinical application of probiotics and prebiotics in the treatment of UC. This review aims to summarize the recent literature as an aid to better understanding how the probiotics and prebiotics contributes to UC while evaluating and prospecting the therapeutic effect of the probiotics and prebiotics in the treatment of UC based on previous publications.
溃疡性结肠炎（UC）越来越常见，逐渐成为一种全球性疾病。UC 是一种炎症性肠病（IBD），是一种终身复发性疾病。UC 作为一种常见疾病，已成为许多人的经济负担，如果不加以预防或治疗，有发展为癌症的潜在风险。多种因素如遗传因素、宿主免疫系统紊乱和环境因素都可能导致 UC。越来越多的研究表明，肠道微生物群作为一种环境因素，在 UC 的发生和发展中起着重要作用。同时，目前的证据表明，操纵肠道微生物群可能代表着预防或管理 UC 的有效治疗方法。此外，治疗 UC 的主要临床药物是氨基水杨酸和皮质类固醇。这些临床药物在治疗 UC 患者时总是存在一些副作用和低成功率。因此，迫切需要安全有效的方法来治疗 UC。基于此，益生菌和益生元可能是治疗 UC 的一种有价值的方法。为了促进益生菌和益生元在 UC 治疗中的广泛临床应用，本综述旨在总结最近的文献，以帮助更好地理解益生菌和益生元如何有助于 UC，并根据以前的出版物评估和预测益生菌和益生元在 UC 治疗中的治疗效果。
