诊断时中性粒细胞与淋巴细胞比值作为肌萎缩侧索硬化生存的生物标志物。
Neutrophil-to-lymphocyte ratio at diagnosis as a biomarker for survival of amyotrophic lateral sclerosis.
机构信息
University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia and.
Department of Neurology, The Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia.
出版信息
Amyotroph Lateral Scler Frontotemporal Degener. 2024 Aug;25(5-6):452-464. doi: 10.1080/21678421.2024.2351187. Epub 2024 May 14.
INTRODUCTION
The neutrophil-to-lymphocyte ratio (NLR) has previously been reported to be associated with survival in ALS. To provide further information about the role of NLR as a biomarker in ALS, we performed a systematic review, analyzed data from our local cohort of ALS subjects and performed a meta-analysis.
METHODS
(1) The systematic review used established methods. (2) Using data from our cohort of subjects, we analyzed the association of NLR with survival. (3) Meta-analysis was performed using previous studies and our local data.
RESULTS
(1) In the systematic review, higher NLR was associated with shorter survival in all studies. (2) In our subjects, survival was significantly shorter in patients in the highest NLR groups. (3) Meta-analysis showed subjects with highest NLR tertile or with NLR >3 had significantly shorter survival than other subjects.
DISCUSSION
This study supports NLR as a biomarker in ALS; high NLR is associated with poor survival.
简介
中性粒细胞与淋巴细胞比值（NLR）先前被报道与 ALS 的生存相关。为了提供关于 NLR 作为 ALS 生物标志物的作用的更多信息，我们进行了系统评价，分析了来自我们当地 ALS 患者队列的数据，并进行了荟萃分析。
方法
（1）系统评价使用了既定的方法。（2）利用我们的队列研究数据，我们分析了 NLR 与生存的关联。（3）使用先前的研究和我们当地的数据进行荟萃分析。
结果
（1）在系统评价中，所有研究均显示较高的 NLR 与较短的生存相关。（2）在我们的研究对象中，NLR 最高组的患者生存时间显著缩短。（3）荟萃分析显示，最高 NLR 三分位组或 NLR>3 的患者的生存时间明显短于其他患者。
讨论
本研究支持 NLR 作为 ALS 的生物标志物；高 NLR 与不良预后相关。
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