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预防痴呆的营养:临床医生的最新进展

Nutrition for dementia prevention: a state of the art update for clinicians.

机构信息

School of Biomedical, Nutritional and Sport Sciences, Human Nutrition & Exercise Research Centre, Newcastle University, Newcastle upon Tyne, UK.

Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

出版信息

Age Ageing. 2024 May 11;53(Suppl 2):ii30-ii38. doi: 10.1093/ageing/afae030.

Abstract

BACKGROUND AND OBJECTIVES

Dementia prevalence continues to rise. It is therefore essential to provide feasible and effective recommendations to encourage healthy brain ageing and reduce dementia risk across the population. Appropriate nutrition represents a potential strategy to mitigate dementia risk and could be recommended by clinicians as part of mid-life health checks and other health initiatives to reduce dementia prevalence. The purpose of this review is to provide a clinician-focused update on the current state of the knowledge on nutrition and dementia prevention.

METHODS

Narrative review.

RESULTS

Strong evidence exists to support the consumption of healthy, plant-based dietary patterns (e.g. Mediterranean, MIND or Nordic diet) for maintaining cognitive function and reducing dementia risk in later life and is supported by dementia prevention guideline from leading public health bodies (e.g. World Health Organization). Emerging evidence suggests potential cognitive benefits of consuming specific nutrients/foods (e.g. n-3 fatty acids or fish, flavonols and B-vitamins) and multi-nutrient compounds (e.g. Fortasyn Connect). Challenges and opportunities for integrating nutritional/dietary interventions for dementia prevention into clinical practice are explored in this review.

CONCLUSIONS

Appropriate nutrition represents an important factor to help facilitate healthy cognitive ageing and allay dementia risk. The information provided in this article can help clinicians provide informed opinions on appropriate nutritional strategies as part of mid-life Health Checks and other risk reduction initiatives.

摘要

背景与目的

痴呆症的患病率持续上升。因此,为了鼓励人群保持大脑健康并降低痴呆症风险,提供可行且有效的建议至关重要。适当的营养是减轻痴呆症风险的潜在策略,临床医生可以在中年健康检查和其他降低痴呆症患病率的健康举措中推荐适当的营养。本综述的目的是为临床医生提供关于营养与痴呆症预防的最新知识。

方法

叙述性综述。

结果

有强有力的证据支持健康的植物性饮食模式(如地中海、MIND 或北欧饮食),以维持认知功能并降低晚年的痴呆症风险,这也得到了领先的公共卫生机构(如世界卫生组织)的痴呆症预防指南的支持。新出现的证据表明,摄入特定营养素/食物(如 n-3 脂肪酸或鱼类、类黄酮和 B 族维生素)和多种营养素化合物(如 Fortasyn Connect)可能对认知有益。本综述探讨了将营养/饮食干预措施整合到临床实践中以预防痴呆症的挑战和机遇。

结论

适当的营养是帮助促进健康认知衰老和降低痴呆症风险的重要因素。本文提供的信息可以帮助临床医生在中年健康检查和其他降低风险的举措中,就适当的营养策略提供明智的意见。

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