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Can nutrition support healthy cognitive ageing and reduce dementia risk?营养支持健康的认知老化并降低痴呆风险吗？
BMJ. 2020 Jun 26;369:m2269. doi: 10.1136/bmj.m2269.
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Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease.饮食与认知老化和阿尔茨海默病中的炎症。
Curr Nutr Rep. 2019 Jun;8(2):53-65. doi: 10.1007/s13668-019-0271-4.
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Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.地中海饮食：鱼类中长链 ω-3 脂肪酸的作用；水果、蔬菜、谷物、咖啡、茶、可可和葡萄酒中的多酚；益生菌和维生素在预防中风、与年龄相关的认知能力下降和阿尔茨海默病中的作用。
Rev Neurol (Paris). 2019 Dec;175(10):724-741. doi: 10.1016/j.neurol.2019.08.005. Epub 2019 Sep 11.
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[Brain food. Importance of nutrition in the prevention and treatment of dementia].[健脑食物。营养在痴呆症预防和治疗中的重要性]
Rev Med Suisse. 2015 Jan 28;11(459):292, 294-7.
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Diet, nutrition and the ageing brain: current evidence and new directions.饮食、营养与大脑衰老：现有证据与新方向。
Proc Nutr Soc. 2018 May;77(2):152-163. doi: 10.1017/S0029665117004177. Epub 2018 Jan 10.
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Nutrition for dementia prevention: a state of the art update for clinicians.预防痴呆的营养：临床医生的最新进展
Age Ageing. 2024 May 11;53(Suppl 2):ii30-ii38. doi: 10.1093/ageing/afae030.
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Dietary Components and Nutritional Strategies for Dementia Prevention in the Elderly.膳食成分与营养策略在老年人痴呆症预防中的应用。
Curr Alzheimer Res. 2023;20(4):224-243. doi: 10.2174/1567205020666230609155932.
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Nutrition and risk of dementia: overview and methodological issues.营养与痴呆风险：概述及方法学问题
Ann N Y Acad Sci. 2016 Mar;1367(1):31-7. doi: 10.1111/nyas.13047.
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Ketogenic Diet for the Treatment and Prevention of Dementia: A Review.生酮饮食治疗和预防痴呆：综述。
J Geriatr Psychiatry Neurol. 2021 Jan;34(1):3-10. doi: 10.1177/0891988720901785. Epub 2020 Jan 30.
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ESPEN guidelines on nutrition in dementia.ESPEN 指南：痴呆症的营养问题。
Clin Nutr. 2015 Dec;34(6):1052-73. doi: 10.1016/j.clnu.2015.09.004. Epub 2015 Sep 25.
引用本文的文献
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Adherence to the cMIND and AIDD diets and their associations with anxiety in older adults in China.中国老年人对cMIND和AIDD饮食的依从性及其与焦虑的关联。
Front Nutr. 2025 Mar 3;12:1548072. doi: 10.3389/fnut.2025.1548072. eCollection 2025.
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Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.营养：阿尔茨海默病发病机制与治疗中不可忽视的因素。
Alzheimers Dement. 2025 Feb;21(2):e14547. doi: 10.1002/alz.14547. Epub 2025 Jan 27.
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Vascular Cognitive Impairment-The Molecular Basis and Potential Influence of the Gut Microbiota on the Pathological Process.血管性认知障碍——肠道微生物群对病理过程的分子基础及潜在影响
Cells. 2024 Nov 27;13(23):1962. doi: 10.3390/cells13231962.
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Integrated multi-omics profiling highlights the diet-gut-brain axis in low-calorie diets promoted novelty-seeking behavior.综合多组学分析揭示了低热量饮食中促进寻求新奇行为的饮食-肠道-脑轴。
Curr Res Food Sci. 2024 Oct 28;9:100897. doi: 10.1016/j.crfs.2024.100897. eCollection 2024.
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Effect of a cash transfer intervention on memory decline and dementia probability in older adults in rural South Africa.现金转移干预对南非农村老年人记忆衰退和痴呆症概率的影响。
Proc Natl Acad Sci U S A. 2024 Oct;121(40):e2321078121. doi: 10.1073/pnas.2321078121. Epub 2024 Sep 19.
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The Effect of a Nutritional Intervention with the Use of Biofortified Beef Meat on Selected Biochemical Parameters in Blood from Older Adults.生物强化牛肉的营养干预对老年人血液中某些生化参数的影响。
Nutrients. 2024 Jul 16;16(14):2281. doi: 10.3390/nu16142281.
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Associations of sugar intake, high-sugar dietary pattern, and the risk of dementia: a prospective cohort study of 210,832 participants.糖摄入量、高糖饮食模式与痴呆症风险的关联：对210,832名参与者的前瞻性队列研究。
BMC Med. 2024 Jul 18;22(1):298. doi: 10.1186/s12916-024-03525-6.
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Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review.限时进食和间歇性禁食对老年人认知功能和心理健康的影响：一项系统综述。
Prev Med Rep. 2024 May 9;42:102757. doi: 10.1016/j.pmedr.2024.102757. eCollection 2024 Jun.
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Clinical trajectories preceding incident dementia up to 15 years before diagnosis: a large prospective cohort study.在诊断前长达 15 年的时间里，出现痴呆症前的临床轨迹：一项大型前瞻性队列研究。
Mol Psychiatry. 2024 Oct;29(10):3097-3105. doi: 10.1038/s41380-024-02570-0. Epub 2024 Apr 27.
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Exploring the Influence of Gut-Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics.探索肠道-大脑轴调节对认知健康的影响：对益生元、益生菌和共生元的综合综述。
Nutrients. 2024 Mar 10;16(6):789. doi: 10.3390/nu16060789.
本文引用的文献
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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing.脑能量拯救：衰老相关神经退行性疾病的新兴治疗理念。
Nat Rev Drug Discov. 2020 Sep;19(9):609-633. doi: 10.1038/s41573-020-0072-x. Epub 2020 Jul 24.
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Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study.改良生酮饮食与阿尔茨海默病高危老年人脑脊液生物标志物谱、脑灌注和脑酮体摄取的改善相关：一项初步研究。
Neurobiol Aging. 2020 Feb;86:54-63. doi: 10.1016/j.neurobiolaging.2019.09.015. Epub 2019 Sep 26.
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Medium-chain triglycerides improved cognition and lipid metabolomics in mild to moderate Alzheimer's disease patients with APOE4: A double-blind, randomized, placebo-controlled crossover trial.中链甘油三酯改善了携带APOE4的轻度至中度阿尔茨海默病患者的认知功能和脂质代谢组学：一项双盲、随机、安慰剂对照交叉试验。
Clin Nutr. 2020 Jul;39(7):2092-2105. doi: 10.1016/j.clnu.2019.10.017. Epub 2019 Oct 22.
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Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometabolic risk factors: A scientific statement from the National Lipid Association Nutrition and Lifestyle Task Force.当前有关低碳水化合物和极低碳水化合物（包括生酮）饮食对体重和其他心血管代谢风险因素管理影响的证据和临床推荐综述：来自国家脂质协会营养与生活方式工作组的科学声明。
J Clin Lipidol. 2019 Sep-Oct;13(5):689-711.e1. doi: 10.1016/j.jacl.2019.08.003. Epub 2019 Sep 13.
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Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study.社交接触与痴呆和认知的关系：白厅 II 队列研究 28 年随访结果。
PLoS Med. 2019 Aug 2;16(8):e1002862. doi: 10.1371/journal.pmed.1002862. eCollection 2019 Aug.
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Association of Lifestyle and Genetic Risk With Incidence of Dementia.生活方式和遗传风险与痴呆症发病率的关联
JAMA. 2019 Aug 6;322(5):430-437. doi: 10.1001/jama.2019.9879.
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Altered SPMs and age-associated decrease in brain DHA in female mice.女性小鼠中 SPM 的改变和与年龄相关的大脑 DHA 减少。
FASEB J. 2019 Sep;33(9):10315-10326. doi: 10.1096/fj.201900423R. Epub 2019 Jul 29.
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Mediterranean diet adherence and cognitive function in older UK adults: the European Prospective Investigation into Cancer and Nutrition-Norfolk (EPIC-Norfolk) Study.地中海饮食依从性与英国老年人认知功能的关系：欧洲癌症与营养前瞻性调查-诺福克研究（EPIC-Norfolk 研究）。
Am J Clin Nutr. 2019 Oct 1;110(4):938-948. doi: 10.1093/ajcn/nqz114.
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A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment.生酮饮料可改善轻度认知障碍患者的大脑能量和某些认知指标。
Alzheimers Dement. 2019 May;15(5):625-634. doi: 10.1016/j.jalz.2018.12.017. Epub 2019 Apr 23.
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Association of Midlife Diet With Subsequent Risk for Dementia.中年饮食与随后痴呆风险的关联。
JAMA. 2019 Mar 12;321(10):957-968. doi: 10.1001/jama.2019.1432.
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