Kobayashi Hiroshi
Department of Gynecology, Ms.Clinic MayOne, Kashihara, Nara, 634-0813, Japan.
Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, 634-8522, Japan.
Heliyon. 2022 Nov 11;8(11):e11487. doi: 10.1016/j.heliyon.2022.e11487. eCollection 2022 Nov.
Epithelial ovarian cancer (EOC) is a gynecologic malignancy with a poor prognosis due to resistance to first-line chemotherapeutic agents. Some cancer cells are primarily dependent on glycolysis, but others favor mitochondrial oxidative phosphorylation (OXPHOS) over glycolysis. Changes in metabolic reprogramming have been reported to be involved in cancer cell survival. In this review, we summarize the metabolic profiles (e.g., metabolic heterogeneity, plasticity, and reprogramming) and adaptation to the dynamic tumor microenvironment and discuss potential novel therapeutic strategies. A literature search was performed between January 2000 and March 2022 in the PubMed and Google Scholar databases using a combination of specific terms. Ovarian cancer cells, including cancer stem cells, depend on glycolysis, OXPHOS, or both for survival. Several environmental stresses, such as nutrient starvation or glucose deprivation, hypoxic stress, acidification, and excessive reactive oxygen species (ROS) generation, reprogram the metabolic pathways to adapt. The interaction between tumors and adjacent stromal cells allows cancer cells to enhance mitochondrial energy metabolism. The metabolic reprogramming varies depending on genomic and epigenetic alterations of metabolism-related genes and the metabolic environment. Developing accurate and non-invasive methods for early identification of metabolic alterations could facilitate optimal cancer diagnosis and treatment. Cancer metabolism research has entered an exciting era where novel strategies targeting metabolic profiling will become more innovative.
上皮性卵巢癌（EOC）是一种妇科恶性肿瘤，由于对一线化疗药物耐药，预后较差。一些癌细胞主要依赖糖酵解，但另一些则更倾向于线粒体氧化磷酸化（OXPHOS）而非糖酵解。据报道，代谢重编程的变化与癌细胞的存活有关。在本综述中，我们总结了代谢特征（如代谢异质性、可塑性和重编程）以及对动态肿瘤微环境的适应性，并讨论了潜在的新型治疗策略。使用特定术语组合在2000年1月至2022年3月期间在PubMed和谷歌学术数据库中进行了文献检索。卵巢癌细胞，包括癌症干细胞，依赖糖酵解、OXPHOS或两者来维持生存。几种环境应激，如营养饥饿或葡萄糖剥夺、缺氧应激、酸化和过量活性氧（ROS）生成，会重新编程代谢途径以实现适应。肿瘤与相邻基质细胞之间的相互作用使癌细胞能够增强线粒体能量代谢。代谢重编程因与代谢相关基因的基因组和表观遗传改变以及代谢环境而异。开发准确且非侵入性的方法用于早期识别代谢改变，可能有助于优化癌症的诊断和治疗。癌症代谢研究已进入一个令人兴奋的时代，针对代谢特征的新策略将变得更加创新。
