Veronez Luciana Chain, Lopes-Júnior Luís Carlos
Department of Childcare and Pediatrics, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP 14040-902, Brazil.
Health Sciences Center, Federal University of Espírito Santo (UFES), Vitoria, ES 29043-900, Brazil.
Explor Target Antitumor Ther. 2024;5(2):400-408. doi: 10.37349/etat.2024.00225. Epub 2024 Apr 24.
In the 21st century, advances in basic research have provided new insights in the field of pediatric oncology. Pediatric patients tend to experience higher levels of distressing symptoms, which together form a symptom cluster. In clinical practice, these symptom clusters are reported daily by children and adolescents with cancer. Translational research has emerged as the translation of new knowledge from basic science into clinical practice. Understanding how neuroimmunoendocrine pathways regulate cancer development and the aspects underlying the specific therapies, such as chemotherapy and immunotherapy, is an important frontier for future research in pediatric oncology. The goal of translational research is to show how different variables in tumor and patient characteristics explain the differential effects of interventions, as translational research provides new insights into the management of cancer symptoms in children and adolescents with cancer. Together, this approach could lead to improvements in pediatric oncology care worldwide.
在21世纪，基础研究的进展为儿科肿瘤学领域提供了新的见解。儿科患者往往会经历更高水平的痛苦症状，这些症状共同构成一个症状群。在临床实践中，患有癌症的儿童和青少年每天都会报告这些症状群。转化研究已成为将基础科学的新知识转化为临床实践的过程。了解神经免疫内分泌途径如何调节癌症发展以及化疗和免疫疗法等特定疗法背后的方面，是儿科肿瘤学未来研究的一个重要前沿领域。转化研究的目标是展示肿瘤和患者特征中的不同变量如何解释干预措施的不同效果，因为转化研究为患有癌症的儿童和青少年的癌症症状管理提供了新的见解。综合起来，这种方法可能会改善全球范围内的儿科肿瘤护理。
