Suzuki F
Gan To Kagaku Ryoho. 1985 Jul;12(7):1445-52.
The antitumor activity of Ge-132 against a variety of allogeneic and syngeneic murine ascites tumors was first evaluated. The antitumor effects of Ge-132 were observed when mice inoculated with Ehrlich carcinoma (allogeneic) or RL male 1 leukemia (syngeneic) cells were treated orally. However, Ge-132 had no activity on a T-cell lymphoma (EL 4, syngeneic) or a methylcholanthrene-induced fibrosarcoma (Meth-A, syngeneic). The antitumor effect of Ge-132 in mice was related to the dose administered as well as the administration schedule. The antitumor activity of Ge-132 was next studied in mice pretreated with some blockers against immunocompetent cells. The antitumor efficacy of Ge-132 was not observed when tumor-bearing mice were treated with trypan blue and carrageenan or monoclonal anti-Thy 1.2 antibody. However, when natural killer cells were eliminated from mice bearing RL male 1 or Ehrlich ascites tumors by treatment with anti-asialo GM 1 antiserum, the antitumor efficacy of the compound was unchanged. These results suggest that Ge-132 is effective against certain ascites tumors regardless of whether the tumor is syngeneic or allogeneic. Further, its effect might be expressed through host defense mechanisms, including macrophages and/or T lymphocytes.
首先评估了Ge - 132对多种同种异体和同基因小鼠腹水肿瘤的抗肿瘤活性。当给接种了艾氏癌（同种异体）或RL雄性1白血病（同基因）细胞的小鼠口服治疗时，观察到了Ge - 132的抗肿瘤作用。然而，Ge - 132对T细胞淋巴瘤（EL 4，同基因）或甲基胆蒽诱导的纤维肉瘤（Meth - A，同基因）没有活性。Ge - 132在小鼠体内的抗肿瘤作用与给药剂量以及给药方案有关。接下来在预先用一些针对免疫活性细胞的阻滞剂处理的小鼠中研究了Ge - 132的抗肿瘤活性。当用台盼蓝和角叉菜胶或单克隆抗Thy 1.2抗体处理荷瘤小鼠时，未观察到Ge - 132的抗肿瘤效果。然而，当用抗唾液酸GM 1抗血清处理携带RL雄性1或艾氏腹水肿瘤的小鼠以消除自然杀伤细胞时，该化合物的抗肿瘤效果未改变。这些结果表明，Ge - 132对某些腹水肿瘤有效，无论肿瘤是同基因的还是同种异体的。此外，其作用可能通过包括巨噬细胞和/或T淋巴细胞在内的宿主防御机制来表达。
