Suzuki F, Brutkiewicz R R, Pollard R B
Anticancer Res. 1985 Sep-Oct;5(5):479-83.
The purpose of this study was to investigate the effective mechanisms of Ge-132, an organogermanium compound with immunomodulatory activity, on experimental murine ascites tumors. The antitumor effects of Ge-132 were observed when mice inoculated with Ehrlich carcinoma (allogeneic) or RL male 1 leukemia (syngeneic) cells were treated orally. However, Ge-132 had no activity on EL-4 lymphoma (syngeneic) or Meth A fibrosarcoma (syngeneic). The antitumor activity of Ge-132 was not observed when tumor-bearing mice were treated with trypan blue, carrageenan, or monoclonal anti-Thy 1.2 antibody. However, when natural killer (NK) cells were eliminated from mice bearing RL male 1 or Ehrlich ascites tumors by treatment with anti-asialo GM1 antiserum, the antitumor activity of the compound was unchanged. This suggests that Ge-132 was effective against certain ascites tumors regardless of whether the tumor was syngeneic or allogeneic. Furthermore, its effect might be expressed through host defense mechanisms, including macrophages and/or T-cells.
本研究的目的是探讨具有免疫调节活性的有机锗化合物Ge-132对实验性小鼠腹水肿瘤的作用机制。给接种艾氏癌（同种异体）或RL雄性1白血病（同基因）细胞的小鼠口服Ge-132后，观察到其抗肿瘤作用。然而，Ge-132对EL-4淋巴瘤（同基因）或Meth A纤维肉瘤（同基因）没有活性。当用台盼蓝、角叉菜胶或单克隆抗Thy 1.2抗体处理荷瘤小鼠时，未观察到Ge-132的抗肿瘤活性。然而，当用抗去唾液酸GM1抗血清处理荷RL雄性1或艾氏腹水瘤的小鼠以消除自然杀伤（NK）细胞时，该化合物的抗肿瘤活性未改变。这表明Ge-132对某些腹水肿瘤有效，无论肿瘤是同基因还是同种异体。此外，其作用可能通过包括巨噬细胞和/或T细胞在内的宿主防御机制来表达。
