Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Stem Cells and Transgenic Technology Research Center (STTRC), Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Curr Stem Cell Res Ther. 2019;14(2):152-168. doi: 10.2174/1574888X13666181018150107.
Diabetes mellitus is an autoimmune disease which causes loss of insulin secretion producing hyperglycemia by promoting progressive destruction of pancreatic β cells. An ideal therapeutic approach to manage diabetes mellitus is pancreatic β cells replacement. The aim of this review article was to evaluate the role of nanofibrous scaffolds and stem cells in the treatment of diabetes mellitus. Various studies have pointed out that application of electrospun biomaterials has considerably attracted researchers in the field of tissue engineering. The principles of cell therapy for diabetes have been reviewed in the first part of this article, while the usability of tissue engineering as a new therapeutic approach is discussed in the second part.
糖尿病是一种自身免疫性疾病，通过促进胰腺β细胞的进行性破坏，导致胰岛素分泌丧失，从而产生高血糖。管理糖尿病的理想治疗方法是胰腺β细胞替代。本文的目的是评估纳米纤维支架和干细胞在糖尿病治疗中的作用。各种研究表明，电纺生物材料的应用极大地吸引了组织工程领域的研究人员。本文的第一部分回顾了细胞治疗糖尿病的原理，第二部分讨论了组织工程作为一种新的治疗方法的可用性。
