Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Biochem Soc Trans. 2024 Jun 26;52(3):1363-1372. doi: 10.1042/BST20231263.
The zinc finger protein of the cerebellum (ZIC) family comprises five members (ZIC1-5), homologous with the odd-paired (OPA) gene in Drosophila melanogila. These transcription factors contain five Cys2His zinc finger domains, constituting one of the most abundant transcription factor families in human cells. ZIC proteins significantly contribute to transcriptional regulation and chromatin remodeling. As a member of the ZIC family, ZIC5 is essential for animal growth and development. Numerous studies have investigated the connection between ZIC proteins and cancer as well as tumor metastases in recent years. Many studies have found that within tumor tissues, the transcription and translation processes increase the expression of ZIC5 which is linked to tumor aggressiveness. This review aims to provide an objective summary of the impact of ZIC5 on tumor metastasis and consider the potential application of ZIC5 targets in both tumor therapy and the early detection of cancer.
小脑锌指蛋白（ZIC）家族包括五个成员（ZIC1-5），与黑腹果蝇中的奇数配对（OPA）基因同源。这些转录因子含有五个 Cys2His 锌指结构域，是人类细胞中最丰富的转录因子家族之一。ZIC 蛋白在转录调控和染色质重塑中起着重要作用。作为 ZIC 家族的一员，ZIC5 对动物的生长和发育至关重要。近年来，许多研究调查了 ZIC 蛋白与癌症以及肿瘤转移之间的联系。许多研究发现，在肿瘤组织中，转录和翻译过程增加了 ZIC5 的表达，这与肿瘤的侵袭性有关。本综述旨在客观总结 ZIC5 对肿瘤转移的影响，并考虑 ZIC5 靶点在肿瘤治疗和癌症早期检测中的潜在应用。
