Ekholdt P F, Gulsvik A, Digranes S, Hovig T, Mellbye O J, Talseth T
Eur J Respir Dis. 1985 May;66(5):353-9.
This case report concerns a 14-year-old boy with a 3 month history of dyspnea and iron deficiency anemia. On admission he had hemoptysis and bilateral pulmonary shadows. Transbronchial lung biopsies showed linear deposits of IgG and C3 in the alveolar basement membrane, but no anti-GBM antibodies were observed in serum or kidney biopsy. The ratio of the T cell subpopulations T4/T8 in peripheral blood was in the early stage, 5 and, thus, elevated. The patient was given prednisolone 1 to 0.25 mg/kg and cyclophosphamide 2 mg/kg with temporary cessation of pulmonary bleeding. Hemoptysis recurred and plasma exchange was performed with success.
本病例报告涉及一名14岁男孩，有3个月的呼吸困难和缺铁性贫血病史。入院时他有咯血和双侧肺部阴影。经支气管肺活检显示肺泡基底膜有IgG和C3的线性沉积，但血清或肾活检中未观察到抗肾小球基底膜抗体。外周血T细胞亚群T4/T8的比例处于早期，为5，因此升高。给予患者泼尼松龙1至0.25mg/kg和环磷酰胺2mg/kg，肺部出血暂时停止。咯血复发，进行血浆置换并取得成功。
