Department of Medicine, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Tex Heart Inst J. 2024 May 15;51(1). doi: 10.14503/THIJ-23-8245.
Turner syndrome is a genetic disorder that occurs in female individuals and is characterized by the absence of 1 of the X chromosomes. This study examined the risk of cardiovascular disease and inpatient clinical outcomes in patients with Turner syndrome.
Data were extracted from the Nationwide Inpatient Sample 2016 database. Propensity score analysis was used to match women with Turner syndrome and women without Turner syndrome admitted to a hospital in the same year to evaluate the risk of cardiovascular disease and inpatient clinical outcomes in patients with Turner syndrome.
After 1:1 matching, 710 women with Turner syndrome and 710 women without Turner syndrome were included in the final analysis. Compared with women without Turner syndrome, women with Turner syndrome were more likely to have a bicuspid aortic valve (9.4% vs 0.01%; P < .01), coarctation of the aorta (5.8% vs 0.3%; P < .01), atrial septal defect (6.1% vs 0.8%; P < .01), and patent ductus arteriosus (4.6% vs 0.6%; P < .01). Patients with Turner syndrome were more likely to have an aortic aneurysm (odds ratio [OR], 2.46 [95% CI, 1.02-5.98]; P = .046), ischemic heart disease (OR, 1.66 [95% CI, 1.10-2.5]; P = .02), heart failure (OR, 3.15 [95% CI, 1.99-4.99]; P < .01), and atrial fibrillation or flutter (OR, 2.48 [95% CI, 1.42-4.34]; P < .01). Patients with Turner syndrome were more likely to have pulmonary arterial hypertension (OR, 2.12 [95% CI, 1.08-4.14]; P = .03) and acute kidney injury (OR, 1.60 [95% CI, 1.06-2.42]; P = .03) and to require mechanical ventilation (OR, 1.66 [95% CI, 1.04-2.68]; P = .04).
Turner syndrome is associated with an increased rate of cardiovascular disease and inpatient complications. These findings suggest that patients with Turner syndrome should be screened and monitored closely for cardiovascular disease and inpatient complications.
特纳综合征是一种发生在女性个体中的遗传疾病，其特征是缺少 1 条 X 染色体。本研究调查了特纳综合征患者患心血管疾病和住院临床结局的风险。
从 2016 年全国住院患者样本数据库中提取数据。采用倾向评分分析，将同一年住院的特纳综合征患者与未患特纳综合征的女性进行匹配，以评估特纳综合征患者患心血管疾病和住院临床结局的风险。
经过 1:1 匹配，共有 710 例特纳综合征患者和 710 例未患特纳综合征的女性纳入最终分析。与未患特纳综合征的女性相比，特纳综合征患者更易发生二叶式主动脉瓣（9.4%比 0.01%；P<.01）、主动脉缩窄（5.8%比 0.3%；P<.01）、房间隔缺损（6.1%比 0.8%；P<.01）和动脉导管未闭（4.6%比 0.6%；P<.01）。特纳综合征患者更易发生主动脉瘤（比值比[OR]，2.46[95%可信区间，1.02-5.98]；P=0.046）、缺血性心脏病（OR，1.66[95%可信区间，1.10-2.5]；P=0.02）、心力衰竭（OR，3.15[95%可信区间，1.99-4.99]；P<.01）和心房颤动或扑动（OR，2.48[95%可信区间，1.42-4.34]；P<.01）。特纳综合征患者更易发生肺动脉高压（OR，2.12[95%可信区间，1.08-4.14]；P=0.03）和急性肾损伤（OR，1.60[95%可信区间，1.06-2.42]；P=0.03），且更需要机械通气（OR，1.66[95%可信区间，1.04-2.68]；P=0.04）。
特纳综合征与心血管疾病和住院并发症发生率的增加有关。这些发现表明，特纳综合征患者应进行心血管疾病和住院并发症的筛查和密切监测。
