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氮化硅涂层钛牙科种植体的成骨和抗菌性能研究。

Investigation on the Osteogenic and Antibacterial Properties of Silicon Nitride-Coated Titanium Dental Implants.

机构信息

Jiangsu Key Laboratory of Advanced Metallic Materials, School of Materials Science and Engineering, Southeast University, Nanjing 211189, China.

Department of Dental Implantology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.

出版信息

ACS Biomater Sci Eng. 2024 Jun 10;10(6):4059-4072. doi: 10.1021/acsbiomaterials.4c00427. Epub 2024 May 15.

Abstract

The silicon nitride (SiN) coating exhibits promising potential in oral applications due to its excellent osteogenic and antibacterial properties. However, a comprehensive investigation of SiN coatings in the context of dental implants is still lacking, especially regarding their corrosion resistance and in performance. In this study, SiN coatings were prepared on a titanium surface using the nonequilibrium magnetron sputtering method. A systematic comparison among the titanium group (Ti), SiN coating group (SiN-Ti), and sandblasted and acid-etched-treated titanium group (SLA-Ti) has been conducted in and in . The results showed that the SiN-Ti group had the best corrosion resistance and antibacterial properties, which were mainly attributed to the dense structure and chemical activity of Si-O and Si-N bonds on the surface. Furthermore, the SiN-Ti group exhibited superior cellular responses in and new bone regeneration and osseointegration in , respectively. In this sense, silicon nitride coating shows promising prospects in the field of dental implantology.

摘要

氮化硅 (SiN) 涂层由于其出色的成骨和抗菌性能,在口腔应用中具有广阔的应用前景。然而,在牙科植入物方面,对 SiN 涂层的全面研究仍然缺乏,特别是关于其耐腐蚀性和性能方面。在这项研究中,使用非平衡磁控溅射法在钛表面制备了氮化硅涂层。在体内和体内条件下,对钛组(Ti)、氮化硅涂层组(SiN-Ti)和喷砂酸蚀处理钛组(SLA-Ti)进行了系统比较。结果表明,SiN-Ti 组具有最佳的耐腐蚀性和抗菌性能,这主要归因于表面 Si-O 和 Si-N 键的致密结构和化学活性。此外,SiN-Ti 组在体内表现出优异的细胞反应,在体内表现出新骨再生和骨整合。从这个意义上说,氮化硅涂层在牙科植入物领域具有广阔的应用前景。

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