Nucleus of Research in Natural Products, Institute of Chemistry, Federal University of Uberlândia -, MG, Uberlândia, Brazil.
Antimicrobial Testing Laboratory, Institute of Biomedical Sciences, Universidade Federal de Uberlândia -, MG, Uberlândia, Brazil.
Chem Biodivers. 2024 Jul;21(7):e202400680. doi: 10.1002/cbdv.202400680. Epub 2024 Jun 22.
The study aimed to assess the chemical composition of Miconia ibaguensis leaves extracts and fractions obtained from the ethanolic extract (EE), along with evaluating their antifungal, antibacterial, antidiabetic, and antioxidant activities. The ethyl acetate fraction (EAF) exhibited potent antifungal activity against Candida spp (1.95-3.90 μg mL) and potent antioxidant activity in the DPPH (1.74±0.07 μg mL), FRAP (654.01±42.09 μmol E/g), and ORAC (3698.88±37.28 μmol E/g) methods. The EE displayed inhibition against the α-amylase enzyme (8.42±0.05 μg mL). Flavonoids, hydrolysable tannins, triterpenoids, and phenolic acids, identified in the EE and fractions via (-)-HPLC-ESI-MS/MS analysis, were found to contribute to the species' biological activity potentially. These findings suggest promising avenues for further research and potential applications in pharmacology and natural products, offering new possibilities in the fight against global health issues.
本研究旨在评估从乙醇提取物（EE）获得的米科尼亚伊巴根斯叶提取物和馏分的化学成分，并评估其抗真菌、抗菌、抗糖尿病和抗氧化活性。乙酸乙酯馏分（EAF）对念珠菌属（1.95-3.90 μg mL）表现出强烈的抗真菌活性，并在 DPPH（1.74±0.07 μg mL）、FRAP（654.01±42.09 μmol E/g）和 ORAC（3698.88±37.28 μmol E/g）方法中表现出强烈的抗氧化活性。EE 对α-淀粉酶酶（8.42±0.05 μg mL）表现出抑制作用。通过（-）-HPLC-ESI-MS/MS 分析，在 EE 和馏分中鉴定出的类黄酮、可水解单宁、三萜类化合物和酚酸，被认为可能对该物种的生物活性有贡献。这些发现为进一步的研究和在药理学和天然产物中的潜在应用提供了有希望的途径，为对抗全球健康问题提供了新的可能性。
