Department of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University, 266555, Qingdao, Shandong, China; Key Lab of Oral Clinical Medicine, The Affiliated Hospital of Qingdao University, 266555, Qingdao, Shandong, China; School of Stomatology, Qingdao University, 266003, Qingdao, Shandong, China.
Department of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University, 266555, Qingdao, Shandong, China; Key Lab of Oral Clinical Medicine, The Affiliated Hospital of Qingdao University, 266555, Qingdao, Shandong, China; School of Stomatology, Qingdao University, 266003, Qingdao, Shandong, China.
Oral Oncol. 2024 Jul;154:106849. doi: 10.1016/j.oraloncology.2024.106849. Epub 2024 May 14.
Oral squamous cell carcinoma (OSCC) is one of the most prevalent malignant tumors in head and neck. However, few studies have focused on the postoperative prognosis of elderly OSCC patients undergoing surgical resection and reconstruction.
We conducted a retrospective study of 349 patients diagnosed OSCC in the Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University from January 2016 to December 2022. Demographic and clinicopathological characteristics were recorded. Kaplan-Meier analysis was performed to identify the impact of age and reconstruction types on the prognosis of OSCC patients. Univariable regression analysis and multivariable Cox analysis were conducted to find independent prognostic factors of the younger and elderly OSCC patients.
Among 349 OSCC patients included in this retrospective study, 241 (69.1 %) were elderly patients and 108 (30.9 %) were younger patients. The two groups were comparable according to the demographic records. The elderly group presented a better recurrence-specific prognosis than that of the younger group (RFS: p = 0.0324). There are no remarkable differences on the prognosis of different reconstructive types. Gender, current address, life habit, invasion patterns, and TNM stage were identified as independent prognostic factors of the younger and elderly OSCC patients.
Elderly OSCC patients achieve a better recurrence-free survival than that of the younger patients. Meanwhile, the recurrence of OSCC patients is independent of their demographic and clinicopathological features. Elderly OSCC patients will benefit from aggressive surgical treatment as the younger patients.
口腔鳞状细胞癌（OSCC）是头颈部最常见的恶性肿瘤之一。然而，很少有研究关注接受手术切除和重建的老年 OSCC 患者的术后预后。
我们对 2016 年 1 月至 2022 年 12 月在青岛大学附属医院口腔颌面外科诊断为 OSCC 的 349 例患者进行了回顾性研究。记录了人口统计学和临床病理特征。采用 Kaplan-Meier 分析确定年龄和重建类型对 OSCC 患者预后的影响。进行单变量回归分析和多变量 Cox 分析，以寻找年轻和老年 OSCC 患者的独立预后因素。
在这项回顾性研究中，349 例 OSCC 患者中，241 例（69.1%）为老年患者，108 例（30.9%）为年轻患者。两组的人口记录相当。老年组的复发特异性预后优于年轻组（RFS：p=0.0324）。不同重建类型的预后无显著差异。性别、现住址、生活习惯、侵犯模式和 TNM 分期被确定为年轻和老年 OSCC 患者的独立预后因素。
老年 OSCC 患者的无复发生存率优于年轻患者。同时，OSCC 患者的复发与他们的人口统计学和临床病理特征无关。老年 OSCC 患者将从积极的手术治疗中受益，就像年轻患者一样。
