Sharifi Mahdi, Jafarzadeh Sadegh, Kiarudi Mohammad Yaser, Hassanzadeh Samira, Rostami Masoud
Refractive Error Research Center, Department of Optometry, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Audiology, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Clin Exp Optom. 2025 Mar;108(2):191-195. doi: 10.1080/08164622.2024.2352503. Epub 2024 May 15.
The visual system plays an important role in the development of the vestibular-ocular reflex (VOR). In clinical practice, the ocular vestibular evoked myogenic potential (oVEMP) test is used to assess contralateral VOR.
This study sought to compare the oVEMP in patients with anisometropic, strabismic, and mixed amblyopia using unilateral and bilateral (simultaneous binaural) stimulation.
Forty-two amblyopic patients (20 males and 22 females) with a mean age of 10.48 ± 4.00 years (range: 5 - 20 years) were examined. The Titmus stereopsis test, alternate cover test, and best-corrected visual acuity were evaluated. Patients were divided into three groups: anisometropic, strabismic, and mixed amblyopia. The oVEMP responses including the amplitude of electrical activity (n1-p1 complex) and the latencies (n1 and p1) of the VOR responses were recorded under unilateral and bilateral stimulations.
In the anisometropic and strabismic group, n1 latency was significantly faster in the non-amblyopic eyes compared to amblyopic eyes (Z = -2.04, = 0.042, andZ = -2.54, = 0.024 respectively). Mean p1 latency was significantly faster in the non-amblyopic eyes compared to the amblyopic eyes of the strabismic group (Z = -2.31, = 0.011)In all groups, the p1 latency was faster in the non-amblyopic eye compared to bilateral stimulation (all, < 0.05). In all groups, the n1-p1 amplitude was not significantly different between the two eyes, and between each eye and bilateral stimulation (all, > 0.05). No significant correlation was found between the depth of amblyopia and n1 and p1 responses (all, > 0.05). In all groups there was no significant difference in the latency of n1 and p1 between the amblyopic eye and bilateral stimulation (all, > 0.05).
Regardless of its type, amblyopia affects vestibular-ocular reflex responses. Further research is warranted to clarify the effect of the disease and its treatment on the ocular-vestibular system.
视觉系统在前庭眼反射（VOR）的发育中起重要作用。在临床实践中，眼前庭诱发肌源性电位（oVEMP）测试用于评估对侧VOR。
本研究旨在比较使用单侧和双侧（同时双耳）刺激时，屈光参差性、斜视性和混合性弱视患者的oVEMP。
检查了42例弱视患者（20例男性和22例女性），平均年龄为10.48±4.00岁（范围：5 - 20岁）。评估了Titmus立体视觉测试、交替遮盖试验和最佳矫正视力。患者分为三组：屈光参差性、斜视性和混合性弱视。在单侧和双侧刺激下记录oVEMP反应，包括电活动幅度（n1 - p1复合波）和VOR反应的潜伏期（n1和p1）。
在屈光参差性和斜视性组中，与弱视眼相比，非弱视眼的n1潜伏期明显更快（分别为Z = -2.04，P = 0.042和Z = -2.54，P = 0.024）。与斜视性组的弱视眼相比，非弱视眼的平均p1潜伏期明显更快（Z = -2.31，P = 0.011）。在所有组中，与双侧刺激相比，非弱视眼的p1潜伏期更快（所有P < 0.05）。在所有组中，两眼之间以及每只眼与双侧刺激之间的n1 - p1幅度无显著差异（所有P > 0.05）。弱视深度与n1和p1反应之间未发现显著相关性（所有P > 0.05）。在所有组中，弱视眼与双侧刺激之间的n1和p1潜伏期无显著差异（所有P > 0.05）。
无论弱视类型如何，都会影响前庭眼反射反应。有必要进一步研究以阐明该疾病及其治疗对眼前庭系统的影响。
