Center for Research on Cardiac Disease in Women, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Bevital AS, Bergen, Norway.
Nutr Metab Cardiovasc Dis. 2024 Aug;34(8):1942-1949. doi: 10.1016/j.numecd.2024.04.002. Epub 2024 Apr 12.
Cardiorespiratory fitness has been postulated to lower chronic inflammation in obesity. We assessed sex-specific associations of inflammation with cardiorespiratory fitness in overweight and obese persons.
Peak oxygen uptake (VO) was measured by treadmill in 566 participants (age 48 ± 9 years, 60% women) with body mass index >27.0 kg/m in the FAT associated CardiOvasculaR dysfunction (FATCOR) study. Fitness was identified from age- and sex specific reference levels of VO. The inflammatory markers C-reactive protein (CRP), serum amyloid A (SAA), kynurenine:tryptophan ratio (KTR) and pyriodoxic acid ratio (PAr) were measured by mass spectrometry. In the total study population 63% had obesity and 74% were cardiorespiratory unfit. Unfit women had the highest fat percentage and the highest serum levels of CRP and SAA (p < 0.05). In multivariable linear regression analyses in women, higher CRP (β -0.15, p = 0.001), SAA (β -0.10, p = 0.03) and PAr (β -0.09, p = 0.03) were associated with lower VO after adjusting for confounders. In multivariable analyses in men, higher PAr (β -0.14, p = 0.02) was associated with lower VO. In multivariable analyses in obese women, higher CRP and PAr remained associated with lower VO (p < 0.05), while in obese men there was no significant association. When normalizing VO for fat-free mass (VO) higher CRP, SAA and PAr index were associated with lower VO in women, while only higher PAr index was associated with lower VO in men.
The association of inflammation with lower cardiorespiratory fitness was more pronounced in women than men, in particular when obesity was present.
URL: http://www.
gov NCT02805478.
心肺适能被认为可以降低肥胖人群的慢性炎症。我们评估了炎症与超重和肥胖人群心肺适能的性别特异性关联。
在 FAT 相关心血管功能障碍（FATCOR）研究中，对 566 名 BMI>27.0kg/m2 的参与者（年龄 48±9 岁，60%为女性）进行跑步机上的峰值摄氧量（VO）测量。根据年龄和性别特异性 VO 参考水平确定适能水平。通过质谱法测量炎症标志物 C 反应蛋白（CRP）、血清淀粉样蛋白 A（SAA）、犬尿氨酸：色氨酸比值（KTR）和吡哆醛酸比值（PAr）。在总研究人群中，63%患有肥胖症，74%心肺功能不健全。不健全的女性体脂百分比最高，血清 CRP 和 SAA 水平最高（p<0.05）。在女性的多元线性回归分析中，CRP（β-0.15，p=0.001）、SAA（β-0.10，p=0.03）和 PAr（β-0.09，p=0.03）水平较高与调整混杂因素后的 VO 降低相关。在男性的多元线性回归分析中，PAr 较高（β-0.14，p=0.02）与 VO 降低相关。在肥胖女性的多元回归分析中，较高的 CRP 和 PAr 仍与 VO 降低相关（p<0.05），而在肥胖男性中则没有显著相关性。当 VO 按去脂体重（VO）标准化时，较高的 CRP、SAA 和 PAr 指数与女性的 VO 降低相关，而只有较高的 PAr 指数与男性的 VO 降低相关。
炎症与心肺适能降低的关联在女性中比男性更为明显，尤其是在存在肥胖的情况下。
网址：http://www.clinicaltrials.gov。
NCT02805478。
